Pulmonary sarcoid-like granulomatosis after multiple vaccinations of a long-term surviving patient with metastatic melanoma

Autoimmune side effects are frequent in patients with cancer treated with immune checkpoint-targeting antibodies, but are rare with cancer vaccines. Here, we present a case report on a patient with metastatic melanoma who developed pulmonary sarcoid-like granulomatosis following repetitive vaccinati...

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Bibliographic Details
Published in:Cancer immunology research 2014-12, Vol.2 (12), p.1148-1153
Main Authors: Bordry, Natacha, Costa-Nunes, Carla-Marisa, Cagnon, Laurène, Gannon, Philippe O, Abed-Maillard, Samia, Baumgaertner, Petra, Murray, Timothy, Letovanec, Igor, Lazor, Romain, Bouchaab, Hasna, Rufer, Nathalie, Romano, Emanuela, Michielin, Olivier, Speiser, Daniel E
Format: Article
Language:English
Subjects:
Adult
Antigens, Neoplasm - immunology
Antigens, Neoplasm - metabolism
Autoimmunity
Brain Neoplasms - diagnosis
Brain Neoplasms - secondary
Cancer Vaccines - administration & dosage
Cancer Vaccines - adverse effects
Humans
Immunohistochemistry
Lymphocytes, Tumor-Infiltrating - immunology
Lymphocytes, Tumor-Infiltrating - metabolism
Lymphomatoid Granulomatosis - diagnosis
Lymphomatoid Granulomatosis - etiology
Magnetic Resonance Imaging
Male
Melanoma - complications
Melanoma - diagnosis
Melanoma - immunology
Melanoma - therapy
Neoplasm Metastasis
Positron-Emission Tomography
Sarcoidosis, Pulmonary - diagnosis
Sarcoidosis, Pulmonary - etiology
Tomography, X-Ray Computed
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Summary:Autoimmune side effects are frequent in patients with cancer treated with immune checkpoint-targeting antibodies, but are rare with cancer vaccines. Here, we present a case report on a patient with metastatic melanoma who developed pulmonary sarcoid-like granulomatosis following repetitive vaccinations with peptides and CpG. Despite multiple metastases, including one lesion in the brain, the patient is alive and well more than 13 years after the diagnosis of metastatic disease. The strongly activated tumor-specific CD8(+) T cells showed robust long-term memory and effector functions. It is possible that long-term survival and adverse autoimmune events may become more common for vaccines inducing robust anticancer immune responses as were present in this patient.
ISSN:2326-6066
2326-6074
DOI:10.1158/2326-6066.CIR-14-0143