Activin signal promotes cancer progression and is involved in cachexia in a subset of pancreatic cancer

Highlights • The plasma activin A level can be a prognostic factor in patents with advanced pancreatic cancer (PC). • The activin signal promotes cancer progression via non-SMAD pathways in a subset of PC and might be involved in cachexia. • The activin signal might be a novel target for the treatme...

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Bibliographic Details
Published in:Cancer letters 2015-01, Vol.356 (2), p.819-827
Main Authors: Togashi, Yosuke, Kogita, Akihiro, Sakamoto, Hiroki, Hayashi, Hidetoshi, Terashima, Masato, de Velasco, Marco A, Sakai, Kazuko, Fujita, Yoshihiko, Tomida, Shuta, Kitano, Masayuki, Okuno, Kiyotaka, Kudo, Masatoshi, Nishio, Kazuto
Format: Article
Language:English
Subjects:
Activin signal
Activins - genetics
Activins - metabolism
Aged
Aged, 80 and over
Animals
Apoptosis
Biomarkers, Tumor - blood
Blotting, Western
Cachexia
Cachexia - diagnosis
Cachexia - etiology
Cachexia - mortality
Cancer therapies
Cell culture
Cell Proliferation
Chemotherapy
Disease Progression
Female
Genes
Hematology, Oncology and Palliative Medicine
Humans
Immunoenzyme Techniques
INHBA
INHBB
Lymphatic Metastasis
Male
Medical prognosis
Metastasis
Mice
Mice, Inbred BALB C
Mice, Nude
Middle Aged
Molecular biology
Neoplasm Staging
Pancreatic cancer
Pancreatic Neoplasms - complications
Pancreatic Neoplasms - metabolism
Pancreatic Neoplasms - mortality
Pancreatic Neoplasms - pathology
Plasma
Prognosis
Real-Time Polymerase Chain Reaction
Reverse Transcriptase Polymerase Chain Reaction
RNA, Messenger - genetics
Signal Transduction
Studies
Survival Rate
Tumor Cells, Cultured
Tumor Stem Cell Assay
Tumors
Xenograft Model Antitumor Assays
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Description
Summary:Highlights • The plasma activin A level can be a prognostic factor in patents with advanced pancreatic cancer (PC). • The activin signal promotes cancer progression via non-SMAD pathways in a subset of PC and might be involved in cachexia. • The activin signal might be a novel target for the treatment of PC.
ISSN:0304-3835
1872-7980
DOI:10.1016/j.canlet.2014.10.037