Spherules and IBV

Infectious bronchitis virus (IBV) is an economically important virus infecting chickens, causing large losses to the poultry industry globally. While vaccines are available, there is a requirement for novel vaccine strategies due to high strain variation and poor cross-protection. This requires a mo...

Full description

Saved in:
Bibliographic Details
Published in:Bioengineered 2014-09, Vol.5 (5), p.288-292
Main Authors: Maier, Helena J, Hawes, Philippa C, Keep, Sarah M, Britton, Paul
Format: Article
Language:English
Subjects:
Animals
coronavirus
Coronavirus Infections - veterinary
double membrane vesicles
Endoplasmic Reticulum - virology
Humans
infectious bronchitis virus
Infectious bronchitis virus - physiology
Intracellular Membranes - chemistry
membrane rearrangements
Poultry Diseases - virology
spherules
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Infectious bronchitis virus (IBV) is an economically important virus infecting chickens, causing large losses to the poultry industry globally. While vaccines are available, there is a requirement for novel vaccine strategies due to high strain variation and poor cross-protection. This requires a more detailed understanding of virus-host cell interactions to identify candidates for targeted virus attenuation. One key area of research in the positive sense RNA virus field, due to its central role in virus replication, is the induction of cellular membrane rearrangements by this class of viruses for the assembly of virus replication complexes. In our recent work, we identified the structures induced by IBV during infection of cultured cells, as well as primary cells and ex vivo organ culture. We identified structures novel to the coronavirus family, which strongly resemble replication sites of other positive sense RNA viruses. We have begun to extend this work using recombinant IBVs, which are chimera of different virus strains to study the role of viral proteins in the induction of membrane rearrangements.
ISSN:2165-5979
2165-5987
2165-5987
DOI:10.4161/bioe.29323