Effect of methyl cellulose on gelation behavior and drug release from poloxamer based ophthalmic formulations

The effect of weight average molecular weight (Mw) of methyl cellulose (MC) on the gelation behavior of Poloxamer 407 (PM) and in vitro release of Ketorolac Tromethamine (KT) from different ophthalmic formulations based on PM is examined. A drop of gelation temperature of PM is observed using MC of...

Full description

Saved in:
Bibliographic Details
Published in:International journal of biological macromolecules 2015-01, Vol.72, p.706-710
Main Authors: Dewan, Mitali, Bhowmick, Biplab, Sarkar, Gunjan, Rana, Dipak, Bain, Mrinal Kanti, Bhowmik, Manas, Chattopadhyay, Dipankar
Format: Article
Language:English
Subjects:
Chemistry, Pharmaceutical
Eye - drug effects
Eye - pathology
Humans
Ketorolac Tromethamine - chemistry
Ketorolac Tromethamine - pharmacology
Methylcellulose - chemistry
Methylcellulose - pharmacology
Molecular Weight
Ophthalmic Solutions - chemistry
Ophthalmic Solutions - pharmacology
Poloxamer - chemistry
Poloxamer - pharmacology
Rheology
Temperature
Viscosity
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:The effect of weight average molecular weight (Mw) of methyl cellulose (MC) on the gelation behavior of Poloxamer 407 (PM) and in vitro release of Ketorolac Tromethamine (KT) from different ophthalmic formulations based on PM is examined. A drop of gelation temperature of PM is observed using MC of various M(w) by test tube tilting method, UV-vis spectroscopy, viscometry and rheometry. It is also observed that the viscosity and gel strength of all the formulations are increased with the increase in Mw of MC. PM with highest Mw of MC provides best drug release property among all the formulations. It is evident from this investigation that there is a distinct effect of M(w) of MC on the gelation behavior of PM as well as on the drug release profile of KT from PM-MC based ophthalmic formulations.
ISSN:0141-8130
1879-0003
DOI:10.1016/j.ijbiomac.2014.09.021