Evaluation of biomaterial containing regenerated cellulose and chitosan incorporated with silver nanoparticles

Biomaterials are used in regenerative medicine, implantable materials, controlled release carriers or scaffolds for tissue engineering. In the present study, the composites containing regenerated cellulose (RC) and chitosan (Ch) impregnated with silver nanoparticles (AgNP) with and without antibioti...

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Bibliographic Details
Published in:International journal of biological macromolecules 2015-01, Vol.72, p.680-686
Main Authors: Ahamed, M I Niyas, Sankar, S, Kashif, P Mohammed, Basha, S K Hayath, Sastry, T P
Format: Article
Language:English
Subjects:
Animals
Biological Dressings
Cellulose - chemistry
Cellulose - therapeutic use
Chitosan - administration & dosage
Chitosan - chemistry
Gentamicins - administration & dosage
Gentamicins - chemistry
Humans
Metal Nanoparticles - administration & dosage
Metal Nanoparticles - chemistry
Rats
Silver - administration & dosage
Silver - chemistry
Wound Healing - drug effects
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Summary:Biomaterials are used in regenerative medicine, implantable materials, controlled release carriers or scaffolds for tissue engineering. In the present study, the composites containing regenerated cellulose (RC) and chitosan (Ch) impregnated with silver nanoparticles (AgNP) with and without antibiotic gentamicin (G) were prepared. The composites prepared were characterized for their physico-chemical and mechanical properties and the results have shown the composite nature. RC-Ch-Ag and RC-Ch-Ag-G composites were used as wound dressing materials in experimental wounds of rats. The healing pattern of the wounds was evaluated by planimetric studies, macroscopic observations, biochemical studies and mechanical properties. The results have shown faster healing pattern in the wounds treated with RC-Ch-Ag and RC-Ch-Ag-G composites compared to untreated control. This study revealed that RC-Ch-Ag composite might be a potential, economical wound dressing material and may be tried on the clinical wounds of animals before being applied on humans.
ISSN:0141-8130
1879-0003
DOI:10.1016/j.ijbiomac.2014.08.055