The CHADS2 and CHA2DS2-VASc scores predict adverse vascular function, ischemic stroke and cardiovascular death in high-risk patients without atrial fibrillation: Role of incorporating PR prolongation

To investigate whether the CHADS2 and CHA2DS2-VASc scores have clinical utility for prediction of adverse vascular function and vascular dysfunction-mediated incident cardiovascular (CV) events among high-risk patients without atrial fibrillation (AF), and the additional value of incorporating PR pr...

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Bibliographic Details
Published in:Atherosclerosis 2014-12, Vol.237 (2), p.504-513
Main Authors: Chan, Yap-Hang, Yiu, Kai-Hang, Lau, Kui-Kai, Yiu, Yuen-Fung, Li, Sheung-Wai, Lam, Tai-Hing, Lau, Chu-Pak, Siu, Chung-Wah, Tse, Hung-Fat
Format: Article
Language:English
Subjects:
Adverse cardiovascular events
Aged
Atrial Fibrillation - physiopathology
Body Mass Index
Cardiovascular continuum
Cardiovascular Diseases - diagnosis
Cardiovascular Diseases - physiopathology
Carotid Intima-Media Thickness
CHADS2 and CHA2DS2-VASc scores
Dilatation
Electrocardiography
Female
Follow-Up Studies
Health Status Indicators
Heart Failure - physiopathology
Humans
Male
Middle Aged
Myocardial Ischemia - pathology
Nitroglycerin - chemistry
PR prolongation
Proportional Hazards Models
Prospective Studies
Pulse Wave Analysis
Risk Assessment
Risk Factors
Risk prediction
ROC Curve
Sex Factors
Tomography, Emission-Computed, Single-Photon
Vascular dysfunction
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Summary:To investigate whether the CHADS2 and CHA2DS2-VASc scores have clinical utility for prediction of adverse vascular function and vascular dysfunction-mediated incident cardiovascular (CV) events among high-risk patients without atrial fibrillation (AF), and the additional value of incorporating PR prolongation to the scores. We analyzed 579 high-risk CV outpatients without clinical AF in a prospective cohort for new-onset ischemic stroke, myocardial infarction (MI), congestive heart failure (CHF), and CV death. Brachial flow-mediated dilation (FMD) and nitroglycerin-mediated dilatation (NMD), carotid intima-media thickness (IMT) and pulse wave velocity (PWV) were determined. Baseline CHADS2 score was associated with lower FMD (Pearson r = −0.16, P 
ISSN:0021-9150
1879-1484
DOI:10.1016/j.atherosclerosis.2014.08.026