Erythrocyte membrane fatty acids in multiple myeloma patients

Highlights • The n-3/n-6 ratio of the erythrocyte membrane FA was significantly lower in MM patients compared to the control group. • The SFA index was significantly higher in the erythrocyte membrane of MM patients. • There is distinct clustering of the variants of individual fatty acids in the ery...

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Bibliographic Details
Published in:Leukemia research 2014-10, Vol.38 (10), p.1260-1265
Main Authors: Jurczyszyn, Artur, Czepiel, Jacek, Gdula-Argasińska, Joanna, Czapkiewicz, Anna, Biesiada, Grażyna, Dróżdż, Mirosław, Perucki, William, Castillo, Jorge J
Format: Article
Language:English
Subjects:
Aged
Aged, 80 and over
Cluster Analysis
Erythrocyte membrane
Erythrocyte Membrane - chemistry
Fatty acids
Fatty Acids - analysis
Female
Gas chromatography
Hematology, Oncology and Palliative Medicine
Humans
Male
Middle Aged
Multiple myeloma
Multiple Myeloma - chemistry
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Summary:Highlights • The n-3/n-6 ratio of the erythrocyte membrane FA was significantly lower in MM patients compared to the control group. • The SFA index was significantly higher in the erythrocyte membrane of MM patients. • There is distinct clustering of the variants of individual fatty acids in the erythrocyte membranes of myeloma patients. • The FA content of erythrocyte membrane could serve as a diagnostic and/or predictive biomarker in MM. • Further research is needed, especially comparing lipid changes with relation to the duration and progression of myeloma.
ISSN:0145-2126
1873-5835
DOI:10.1016/j.leukres.2014.08.009