Chronic lymphocytic leukaemia cells become both activated and immunosuppressive following interaction with CD3 and CD28 stimulated PBMC

Highlights • CLL cells become activated by co-culture with CD3/CD28 stimulated healthy PBMC. • The activated CLL can subsequently suppress the proliferative responses of T-cells. • Suppression requires cell contact but does not involve induction of T-cell apoptosis.

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Bibliographic Details
Published in:Leukemia research 2014-10, Vol.38 (10), p.1217-1223
Main Authors: Hock, B.D, Macpherson, S.A, Fernyhough, L.J, McKenzie, J.L
Format: Article
Language:English
Subjects:
Activation
Aged
Aged, 80 and over
CD28 Antigens - immunology
CD3 Complex - immunology
Cell Proliferation
Chronic lymphocytic leukaemia
Coculture Techniques
Female
Flow Cytometry
Hematology, Oncology and Palliative Medicine
Humans
Immune Tolerance - immunology
Immunosuppression
Leukemia, Lymphocytic, Chronic, B-Cell - immunology
Lymphocyte Activation - immunology
Male
Micro-environment
Middle Aged
T-cell
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Description
Summary:Highlights • CLL cells become activated by co-culture with CD3/CD28 stimulated healthy PBMC. • The activated CLL can subsequently suppress the proliferative responses of T-cells. • Suppression requires cell contact but does not involve induction of T-cell apoptosis.
ISSN:0145-2126
1873-5835
DOI:10.1016/j.leukres.2014.06.004