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Tropism distribution among antiretroviral-naive HIV-2-infected patients
HIV-2 susceptibility to maraviroc has been recently established for R5-tropic viruses. However, there is only few data about HIV-2 tropism distribution during HIV-2 infection and no data are available in antiretroviral-naive patients. In this work, we aimed to characterize for the first time the dis...
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Published in: | Antiviral therapy 2014-01, Vol.19, p.A70-A70 |
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Main Authors: | , , , , , , , , , , |
Format: | Article |
Language: | English |
Subjects: | |
Online Access: | Get full text |
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Summary: | HIV-2 susceptibility to maraviroc has been recently established for R5-tropic viruses. However, there is only few data about HIV-2 tropism distribution during HIV-2 infection and no data are available in antiretroviral-naive patients. In this work, we aimed to characterize for the first time the distribution of tropism in HIV-2 antiretroviral-naive patients. Patients included in the ANRS CO5 HIV-2 Cohort, for whom a first PBMC sample was available since time of inclusion and before any antiretroviral therapy, were screened. Tropism was determined by a genotypic tropism test using V3 loop sequencing in proviral DNA. Patients' characteristics, plasma viral load, CD4 cell count and CDC clinical stage at the time of sampling were also collected. This first description of tropism distribution in HIV-2 antiretroviral-naive patients showed that 11% of patients displayed X4-tropic viruses. X4 tropism was also associated with low CD4 cell counts. These findings are similar to those already described in HIV-1 infection. |
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ISSN: | 1359-6535 |