Rosiglitazone attenuates hyperglycemia-enhanced hemorrhagic transformation after transient focal ischemia in rats

Highlights • We used a rat model of hyperglycemia-enhanced hemorrhagic transformation. • Rosiglitazone reduced infarct volume after focal ischemia. • Rosiglitazone reduced hemorrhagic transformation. • Rosiglitazone increased expression of collagen IV by preservation of GLUT1.

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Bibliographic Details
Published in:Neuroscience 2013-10, Vol.250, p.651-657
Main Authors: Zhang, F.H, Lin, Y.H, Huang, H.G, Sun, J.Z, Wen, S.Q, Lou, M
Format: Article
Language:English
Subjects:
Animals
Biological and medical sciences
Blood Glucose - metabolism
Collagen Type IV - biosynthesis
Fundamental and applied biological sciences. Psychology
Glucose Transporter Type 1 - biosynthesis
Glucose Transporter Type 1 - genetics
Hemoglobins - metabolism
hemorrhagic transformation
hyperglycemia
Hyperglycemia - complications
Hyperglycemia - pathology
Hypoglycemic Agents - pharmacology
Immunohistochemistry
Infarction, Middle Cerebral Artery - pathology
Intracranial Hemorrhages - etiology
Intracranial Hemorrhages - pathology
Intracranial Hemorrhages - prevention & control
Ischemic Attack, Transient - complications
Ischemic Attack, Transient - pathology
Male
Medical sciences
middle cerebral artery occlusion
Nervous System Diseases - etiology
Nervous System Diseases - physiopathology
Neurology
Rats
Rats, Sprague-Dawley
rosiglitazone
Thiazolidinediones - pharmacology
Vascular diseases and vascular malformations of the nervous system
Vertebrates: nervous system and sense organs
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Description
Summary:Highlights • We used a rat model of hyperglycemia-enhanced hemorrhagic transformation. • Rosiglitazone reduced infarct volume after focal ischemia. • Rosiglitazone reduced hemorrhagic transformation. • Rosiglitazone increased expression of collagen IV by preservation of GLUT1.
ISSN:0306-4522
1873-7544
DOI:10.1016/j.neuroscience.2013.07.039