Expression analysis of genes involved in TLR2-related signaling pathway: Inflammation and apoptosis after ischemic brain injury

Highlights ► Toll-like receptor 2 (TLR2) signaling pathway is active in mouse post ischemic brain. ► Proinflammatory response reaches its maximum 1 week after introduced brain ischemia. ► TLR2 loss results in the decrease of proinflammatory response after brain ischemia. ► TLR2 loss results in highe...

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Bibliographic Details
Published in:Neuroscience 2013-05, Vol.238, p.87-96
Main Authors: Winters, L, Winters, T, Gorup, D, Mitrečić, D, Ćurlin, M, Križ, J, Gajović, S
Format: Article
Language:English
Subjects:
Animals
apoptosis
Apoptosis - genetics
Biological and medical sciences
brain
Brain - metabolism
Brain Ischemia - complications
Brain Ischemia - genetics
Brain Ischemia - metabolism
Caspase 8 - genetics
Caspase 8 - metabolism
Fundamental and applied biological sciences. Psychology
Gene Expression
inflammation
Inflammation - etiology
Inflammation - genetics
Inflammation - metabolism
ischemia
Medical sciences
Mice
Mice, Knockout
mouse
Neurology
Signal Transduction - genetics
Stroke - complications
Stroke - genetics
Stroke - metabolism
TLR2
Toll-Like Receptor 2 - genetics
Toll-Like Receptor 2 - metabolism
Vascular diseases and vascular malformations of the nervous system
Vertebrates: nervous system and sense organs
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Summary:Highlights ► Toll-like receptor 2 (TLR2) signaling pathway is active in mouse post ischemic brain. ► Proinflammatory response reaches its maximum 1 week after introduced brain ischemia. ► TLR2 loss results in the decrease of proinflammatory response after brain ischemia. ► TLR2 loss results in higher expression of apoptotic factor Casp8.
ISSN:0306-4522
1873-7544
DOI:10.1016/j.neuroscience.2013.02.001