Caffeic acid treatment alters the extracellular adenine nucleotide hydrolysis in platelets and lymphocytes of adult rats

► In platelets, caffeic acid altered the adenine nucleotides hydrolysis. ► Caffeic acid decreased the platelet aggregation in the doses of 10, 50 at 100mg/kg. ► Caffeic acid increased the NTPDase and adenosine deaminase activities in lymphocytes. ► The caffeic acid altered the purinergic signaling i...

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Published in:Food and chemical toxicology 2013-06, Vol.56, p.459-466
Main Authors: Anwar, Javed, Spanevello, Roselia Maria, Pimentel, Victor Camera, Gutierres, Jessié, Thomé, Gustavo, Cardoso, Andreia, Zanini, Daniela, Martins, Caroline, Palma, Heloisa Einloft, Bagatini, Margarete Dulce, Baldissarelli, Jucimara, Schmatz, Roberta, Leal, Cláudio Alberto Martins, Costa, Pauline da, Morsch, Vera Maria, Schetinger, Maria Rosa Chitolina
Format: Article
Language:English
Subjects:
Adenine Nucleotides - metabolism
Adenosine Deaminase - metabolism
Adenosine Triphosphatases - metabolism
Animals
Biological and medical sciences
Blood Platelets - drug effects
Blood Platelets - enzymology
Caffeic acid
Caffeic Acids - pharmacology
Dose-Response Relationship, Drug
Ectonucleotidases
Hydrolysis
Lymphocytes
Lymphocytes - drug effects
Lymphocytes - enzymology
Male
Medical sciences
Phosphoric Diester Hydrolases - metabolism
Platelet aggregation
Platelet Aggregation - drug effects
Platelets
Pyrophosphatases - metabolism
Rats
Rats, Wistar
Toxicology
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Summary:► In platelets, caffeic acid altered the adenine nucleotides hydrolysis. ► Caffeic acid decreased the platelet aggregation in the doses of 10, 50 at 100mg/kg. ► Caffeic acid increased the NTPDase and adenosine deaminase activities in lymphocytes. ► The caffeic acid altered the purinergic signaling in the different cells. This study evaluated the effects of caffeic acid on ectonucleotidase activities such as NTPDase (nucleoside triphosphate diphosphohydrolase), Ecto-NPP (nucleotide pyrophosphatase/phosphodiesterase), 5′-nucleotidase and adenosine deaminase (ADA) in platelets and lymphocytes of rats, as well as in the profile of platelet aggregation. Animals were divided into five groups: I (control); II (oil); III (caffeic acid 10mg/kg); IV (caffeic acid 50mg/kg); and V (caffeic acid 100mg/kg). Animals were treated with caffeic acid diluted in oil for 30days. In platelets, caffeic acid decreased the ATP hydrolysis and increased ADP hydrolysis in groups III, IV and V when compared to control (P
ISSN:0278-6915
1873-6351
DOI:10.1016/j.fct.2013.02.030