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Caffeic acid treatment alters the extracellular adenine nucleotide hydrolysis in platelets and lymphocytes of adult rats
► In platelets, caffeic acid altered the adenine nucleotides hydrolysis. ► Caffeic acid decreased the platelet aggregation in the doses of 10, 50 at 100mg/kg. ► Caffeic acid increased the NTPDase and adenosine deaminase activities in lymphocytes. ► The caffeic acid altered the purinergic signaling i...
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| Published in: | Food and chemical toxicology 2013-06, Vol.56, p.459-466 |
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| creator | Anwar, Javed Spanevello, Roselia Maria Pimentel, Victor Camera Gutierres, Jessié Thomé, Gustavo Cardoso, Andreia Zanini, Daniela Martins, Caroline Palma, Heloisa Einloft Bagatini, Margarete Dulce Baldissarelli, Jucimara Schmatz, Roberta Leal, Cláudio Alberto Martins Costa, Pauline da Morsch, Vera Maria Schetinger, Maria Rosa Chitolina |
| description | ► In platelets, caffeic acid altered the adenine nucleotides hydrolysis. ► Caffeic acid decreased the platelet aggregation in the doses of 10, 50 at 100mg/kg. ► Caffeic acid increased the NTPDase and adenosine deaminase activities in lymphocytes. ► The caffeic acid altered the purinergic signaling in the different cells.
This study evaluated the effects of caffeic acid on ectonucleotidase activities such as NTPDase (nucleoside triphosphate diphosphohydrolase), Ecto-NPP (nucleotide pyrophosphatase/phosphodiesterase), 5′-nucleotidase and adenosine deaminase (ADA) in platelets and lymphocytes of rats, as well as in the profile of platelet aggregation. Animals were divided into five groups: I (control); II (oil); III (caffeic acid 10mg/kg); IV (caffeic acid 50mg/kg); and V (caffeic acid 100mg/kg). Animals were treated with caffeic acid diluted in oil for 30days. In platelets, caffeic acid decreased the ATP hydrolysis and increased ADP hydrolysis in groups III, IV and V when compared to control (P |
| doi_str_mv | 10.1016/j.fct.2013.02.030 |
| format | article |
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This study evaluated the effects of caffeic acid on ectonucleotidase activities such as NTPDase (nucleoside triphosphate diphosphohydrolase), Ecto-NPP (nucleotide pyrophosphatase/phosphodiesterase), 5′-nucleotidase and adenosine deaminase (ADA) in platelets and lymphocytes of rats, as well as in the profile of platelet aggregation. Animals were divided into five groups: I (control); II (oil); III (caffeic acid 10mg/kg); IV (caffeic acid 50mg/kg); and V (caffeic acid 100mg/kg). Animals were treated with caffeic acid diluted in oil for 30days. In platelets, caffeic acid decreased the ATP hydrolysis and increased ADP hydrolysis in groups III, IV and V when compared to control (P<0.05). The 5′-nucleotidase activity was decreased, while E-NPP and ADA activities were increased in platelets of rats of groups III, IV and V (P<0.05). Caffeic acid reduced significantly the platelet aggregation in the animals of groups III, IV and V in relation to group I (P<0.05). In lymphocytes, the NTPDase and ADA activities were increased in all groups treated with caffeic acid when compared to control (P<0.05). These findings demonstrated that the enzymes were altered in tissues by caffeic acid and this compound decreased the platelet aggregation suggesting that caffeic acid should be considered a potentially therapeutic agent in disorders related to the purinergic system.</description><identifier>ISSN: 0278-6915</identifier><identifier>EISSN: 1873-6351</identifier><identifier>DOI: 10.1016/j.fct.2013.02.030</identifier><identifier>PMID: 23454297</identifier><identifier>CODEN: FCTOD7</identifier><language>eng</language><publisher>Oxford: Elsevier Ltd</publisher><subject>Adenine Nucleotides - metabolism ; Adenosine Deaminase - metabolism ; Adenosine Triphosphatases - metabolism ; Animals ; Biological and medical sciences ; Blood Platelets - drug effects ; Blood Platelets - enzymology ; Caffeic acid ; Caffeic Acids - pharmacology ; Dose-Response Relationship, Drug ; Ectonucleotidases ; Hydrolysis ; Lymphocytes ; Lymphocytes - drug effects ; Lymphocytes - enzymology ; Male ; Medical sciences ; Phosphoric Diester Hydrolases - metabolism ; Platelet aggregation ; Platelet Aggregation - drug effects ; Platelets ; Pyrophosphatases - metabolism ; Rats ; Rats, Wistar ; Toxicology</subject><ispartof>Food and chemical toxicology, 2013-06, Vol.56, p.459-466</ispartof><rights>2013 Elsevier Ltd</rights><rights>2014 INIST-CNRS</rights><rights>Copyright © 2013 Elsevier Ltd. All rights reserved.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c459t-c7e3509e764da34b2b4613b8990b6b277ee0ac2bb79e258d65ca790b3e41da943</citedby><cites>FETCH-LOGICAL-c459t-c7e3509e764da34b2b4613b8990b6b277ee0ac2bb79e258d65ca790b3e41da943</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=27285847$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/23454297$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Anwar, Javed</creatorcontrib><creatorcontrib>Spanevello, Roselia Maria</creatorcontrib><creatorcontrib>Pimentel, Victor Camera</creatorcontrib><creatorcontrib>Gutierres, Jessié</creatorcontrib><creatorcontrib>Thomé, Gustavo</creatorcontrib><creatorcontrib>Cardoso, Andreia</creatorcontrib><creatorcontrib>Zanini, Daniela</creatorcontrib><creatorcontrib>Martins, Caroline</creatorcontrib><creatorcontrib>Palma, Heloisa Einloft</creatorcontrib><creatorcontrib>Bagatini, Margarete Dulce</creatorcontrib><creatorcontrib>Baldissarelli, Jucimara</creatorcontrib><creatorcontrib>Schmatz, Roberta</creatorcontrib><creatorcontrib>Leal, Cláudio Alberto Martins</creatorcontrib><creatorcontrib>Costa, Pauline da</creatorcontrib><creatorcontrib>Morsch, Vera Maria</creatorcontrib><creatorcontrib>Schetinger, Maria Rosa Chitolina</creatorcontrib><title>Caffeic acid treatment alters the extracellular adenine nucleotide hydrolysis in platelets and lymphocytes of adult rats</title><title>Food and chemical toxicology</title><addtitle>Food Chem Toxicol</addtitle><description>► In platelets, caffeic acid altered the adenine nucleotides hydrolysis. ► Caffeic acid decreased the platelet aggregation in the doses of 10, 50 at 100mg/kg. ► Caffeic acid increased the NTPDase and adenosine deaminase activities in lymphocytes. ► The caffeic acid altered the purinergic signaling in the different cells.
This study evaluated the effects of caffeic acid on ectonucleotidase activities such as NTPDase (nucleoside triphosphate diphosphohydrolase), Ecto-NPP (nucleotide pyrophosphatase/phosphodiesterase), 5′-nucleotidase and adenosine deaminase (ADA) in platelets and lymphocytes of rats, as well as in the profile of platelet aggregation. Animals were divided into five groups: I (control); II (oil); III (caffeic acid 10mg/kg); IV (caffeic acid 50mg/kg); and V (caffeic acid 100mg/kg). Animals were treated with caffeic acid diluted in oil for 30days. In platelets, caffeic acid decreased the ATP hydrolysis and increased ADP hydrolysis in groups III, IV and V when compared to control (P<0.05). The 5′-nucleotidase activity was decreased, while E-NPP and ADA activities were increased in platelets of rats of groups III, IV and V (P<0.05). Caffeic acid reduced significantly the platelet aggregation in the animals of groups III, IV and V in relation to group I (P<0.05). In lymphocytes, the NTPDase and ADA activities were increased in all groups treated with caffeic acid when compared to control (P<0.05). These findings demonstrated that the enzymes were altered in tissues by caffeic acid and this compound decreased the platelet aggregation suggesting that caffeic acid should be considered a potentially therapeutic agent in disorders related to the purinergic system.</description><subject>Adenine Nucleotides - metabolism</subject><subject>Adenosine Deaminase - metabolism</subject><subject>Adenosine Triphosphatases - metabolism</subject><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>Blood Platelets - drug effects</subject><subject>Blood Platelets - enzymology</subject><subject>Caffeic acid</subject><subject>Caffeic Acids - pharmacology</subject><subject>Dose-Response Relationship, Drug</subject><subject>Ectonucleotidases</subject><subject>Hydrolysis</subject><subject>Lymphocytes</subject><subject>Lymphocytes - drug effects</subject><subject>Lymphocytes - enzymology</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Phosphoric Diester Hydrolases - metabolism</subject><subject>Platelet aggregation</subject><subject>Platelet Aggregation - drug effects</subject><subject>Platelets</subject><subject>Pyrophosphatases - metabolism</subject><subject>Rats</subject><subject>Rats, Wistar</subject><subject>Toxicology</subject><issn>0278-6915</issn><issn>1873-6351</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2013</creationdate><recordtype>article</recordtype><recordid>eNqFkb2O1DAURi0EYmcXHoAGuUGiSfBf4kRUaAQs0ko0UFs39o3GIycZbAdt3h6PZoAOKhc-37Xvdwh5xVnNGW_fHevR5lowLmsmaibZE7LjnZZVKxv-lOyY0F3V9ry5IbcpHRljmuv2ObkRUjVK9HpHHvcwjugtBesdzREhTzhnCiFjTDQfkOJjjmAxhDVApOBw9jPSebUBl-wd0sPm4hK25BP1Mz0FyBgwJwqzo2GbTofFbhkTXcaSXkOmEXJ6QZ6NEBK-vJ535Punj9_299XD189f9h8eKquaPldWo2xYj7pVDqQaxKBaLoeu79nQDkJrRAZWDIPuUTSdaxsLutxJVNxBr-QdeXuZe4rLjxVTNpNP521gxmVNhpeumChddP9HpWobrZXmBeUX1MYlpYijOUU_QdwMZ-bsxhxNcWPObgwTprgpmdfX8eswofuT-C2jAG-uACQLYYwwW5_-clp0TafO3PsLh6W3nx6jSdbjbNH5iOVRt_h_fOMXsUOt1w</recordid><startdate>20130601</startdate><enddate>20130601</enddate><creator>Anwar, Javed</creator><creator>Spanevello, Roselia Maria</creator><creator>Pimentel, Victor Camera</creator><creator>Gutierres, Jessié</creator><creator>Thomé, Gustavo</creator><creator>Cardoso, Andreia</creator><creator>Zanini, Daniela</creator><creator>Martins, Caroline</creator><creator>Palma, Heloisa Einloft</creator><creator>Bagatini, Margarete Dulce</creator><creator>Baldissarelli, Jucimara</creator><creator>Schmatz, Roberta</creator><creator>Leal, Cláudio Alberto Martins</creator><creator>Costa, Pauline da</creator><creator>Morsch, Vera Maria</creator><creator>Schetinger, Maria Rosa Chitolina</creator><general>Elsevier Ltd</general><general>Elsevier</general><scope>6I.</scope><scope>AAFTH</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>7T5</scope><scope>7TM</scope><scope>7U7</scope><scope>C1K</scope><scope>H94</scope></search><sort><creationdate>20130601</creationdate><title>Caffeic acid treatment alters the extracellular adenine nucleotide hydrolysis in platelets and lymphocytes of adult rats</title><author>Anwar, Javed ; Spanevello, Roselia Maria ; Pimentel, Victor Camera ; Gutierres, Jessié ; Thomé, Gustavo ; Cardoso, Andreia ; Zanini, Daniela ; Martins, Caroline ; Palma, Heloisa Einloft ; Bagatini, Margarete Dulce ; Baldissarelli, Jucimara ; Schmatz, Roberta ; Leal, Cláudio Alberto Martins ; Costa, Pauline da ; Morsch, Vera Maria ; Schetinger, Maria Rosa Chitolina</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c459t-c7e3509e764da34b2b4613b8990b6b277ee0ac2bb79e258d65ca790b3e41da943</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2013</creationdate><topic>Adenine Nucleotides - metabolism</topic><topic>Adenosine Deaminase - metabolism</topic><topic>Adenosine Triphosphatases - metabolism</topic><topic>Animals</topic><topic>Biological and medical sciences</topic><topic>Blood Platelets - drug effects</topic><topic>Blood Platelets - enzymology</topic><topic>Caffeic acid</topic><topic>Caffeic Acids - pharmacology</topic><topic>Dose-Response Relationship, Drug</topic><topic>Ectonucleotidases</topic><topic>Hydrolysis</topic><topic>Lymphocytes</topic><topic>Lymphocytes - drug effects</topic><topic>Lymphocytes - enzymology</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Phosphoric Diester Hydrolases - metabolism</topic><topic>Platelet aggregation</topic><topic>Platelet Aggregation - drug effects</topic><topic>Platelets</topic><topic>Pyrophosphatases - metabolism</topic><topic>Rats</topic><topic>Rats, Wistar</topic><topic>Toxicology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Anwar, Javed</creatorcontrib><creatorcontrib>Spanevello, Roselia Maria</creatorcontrib><creatorcontrib>Pimentel, Victor Camera</creatorcontrib><creatorcontrib>Gutierres, Jessié</creatorcontrib><creatorcontrib>Thomé, Gustavo</creatorcontrib><creatorcontrib>Cardoso, Andreia</creatorcontrib><creatorcontrib>Zanini, Daniela</creatorcontrib><creatorcontrib>Martins, Caroline</creatorcontrib><creatorcontrib>Palma, Heloisa Einloft</creatorcontrib><creatorcontrib>Bagatini, Margarete Dulce</creatorcontrib><creatorcontrib>Baldissarelli, Jucimara</creatorcontrib><creatorcontrib>Schmatz, Roberta</creatorcontrib><creatorcontrib>Leal, Cláudio Alberto Martins</creatorcontrib><creatorcontrib>Costa, Pauline da</creatorcontrib><creatorcontrib>Morsch, Vera Maria</creatorcontrib><creatorcontrib>Schetinger, Maria Rosa Chitolina</creatorcontrib><collection>ScienceDirect Open Access Titles</collection><collection>Elsevier:ScienceDirect:Open Access</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>Immunology Abstracts</collection><collection>Nucleic Acids Abstracts</collection><collection>Toxicology Abstracts</collection><collection>Environmental Sciences and Pollution Management</collection><collection>AIDS and Cancer Research Abstracts</collection><jtitle>Food and chemical toxicology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Anwar, Javed</au><au>Spanevello, Roselia Maria</au><au>Pimentel, Victor Camera</au><au>Gutierres, Jessié</au><au>Thomé, Gustavo</au><au>Cardoso, Andreia</au><au>Zanini, Daniela</au><au>Martins, Caroline</au><au>Palma, Heloisa Einloft</au><au>Bagatini, Margarete Dulce</au><au>Baldissarelli, Jucimara</au><au>Schmatz, Roberta</au><au>Leal, Cláudio Alberto Martins</au><au>Costa, Pauline da</au><au>Morsch, Vera Maria</au><au>Schetinger, Maria Rosa Chitolina</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Caffeic acid treatment alters the extracellular adenine nucleotide hydrolysis in platelets and lymphocytes of adult rats</atitle><jtitle>Food and chemical toxicology</jtitle><addtitle>Food Chem Toxicol</addtitle><date>2013-06-01</date><risdate>2013</risdate><volume>56</volume><spage>459</spage><epage>466</epage><pages>459-466</pages><issn>0278-6915</issn><eissn>1873-6351</eissn><coden>FCTOD7</coden><abstract>► In platelets, caffeic acid altered the adenine nucleotides hydrolysis. ► Caffeic acid decreased the platelet aggregation in the doses of 10, 50 at 100mg/kg. ► Caffeic acid increased the NTPDase and adenosine deaminase activities in lymphocytes. ► The caffeic acid altered the purinergic signaling in the different cells.
This study evaluated the effects of caffeic acid on ectonucleotidase activities such as NTPDase (nucleoside triphosphate diphosphohydrolase), Ecto-NPP (nucleotide pyrophosphatase/phosphodiesterase), 5′-nucleotidase and adenosine deaminase (ADA) in platelets and lymphocytes of rats, as well as in the profile of platelet aggregation. Animals were divided into five groups: I (control); II (oil); III (caffeic acid 10mg/kg); IV (caffeic acid 50mg/kg); and V (caffeic acid 100mg/kg). Animals were treated with caffeic acid diluted in oil for 30days. In platelets, caffeic acid decreased the ATP hydrolysis and increased ADP hydrolysis in groups III, IV and V when compared to control (P<0.05). The 5′-nucleotidase activity was decreased, while E-NPP and ADA activities were increased in platelets of rats of groups III, IV and V (P<0.05). Caffeic acid reduced significantly the platelet aggregation in the animals of groups III, IV and V in relation to group I (P<0.05). In lymphocytes, the NTPDase and ADA activities were increased in all groups treated with caffeic acid when compared to control (P<0.05). These findings demonstrated that the enzymes were altered in tissues by caffeic acid and this compound decreased the platelet aggregation suggesting that caffeic acid should be considered a potentially therapeutic agent in disorders related to the purinergic system.</abstract><cop>Oxford</cop><pub>Elsevier Ltd</pub><pmid>23454297</pmid><doi>10.1016/j.fct.2013.02.030</doi><tpages>8</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | Food and chemical toxicology, 2013-06, Vol.56, p.459-466 |
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| language | eng |
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| source | ScienceDirect Journals |
| subjects | Adenine Nucleotides - metabolism Adenosine Deaminase - metabolism Adenosine Triphosphatases - metabolism Animals Biological and medical sciences Blood Platelets - drug effects Blood Platelets - enzymology Caffeic acid Caffeic Acids - pharmacology Dose-Response Relationship, Drug Ectonucleotidases Hydrolysis Lymphocytes Lymphocytes - drug effects Lymphocytes - enzymology Male Medical sciences Phosphoric Diester Hydrolases - metabolism Platelet aggregation Platelet Aggregation - drug effects Platelets Pyrophosphatases - metabolism Rats Rats, Wistar Toxicology |
| title | Caffeic acid treatment alters the extracellular adenine nucleotide hydrolysis in platelets and lymphocytes of adult rats |
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