Deficient functional recovery after facial nerve crush in rats is associated with restricted rearrangements of synaptic terminals in the facial nucleus

Highlights • Muscle reinnervation after facial nerve crush (axonotmesis) in rats is precise. • Full functional recovery after crush is not achieved. • Functional deficits are associated with deficient synaptic inputs to motoneurons.

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Bibliographic Details
Published in:Neuroscience 2013-09, Vol.248, p.307-318
Main Authors: Hundeshagen, G, Szameit, K, Thieme, H, Finkensieper, M, Angelov, D.N, Guntinas-Lichius, O, Irintchev, A
Format: Article
Language:English
Subjects:
Animals
Biological and medical sciences
cholinergic synapses
Disease Models, Animal
Facial Nerve - physiopathology
Facial Nerve Injuries - pathology
Facial Nerve Injuries - physiopathology
Facial Nerve Injuries - rehabilitation
Facial Nucleus - cytology
Facial Nucleus - pathology
Facial Nucleus - physiopathology
Fundamental and applied biological sciences. Psychology
Male
microglia
Motor Neurons - cytology
Motor Neurons - pathology
Nerve Crush - methods
Nerve Regeneration
Neurology
peripheral nerve regeneration
Presynaptic Terminals - pathology
Rats
Recovery of Function
synaptic plasticity
Vertebrates: nervous system and sense organs
vesicular glutamate transporter 2
whisking
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Description
Summary:Highlights • Muscle reinnervation after facial nerve crush (axonotmesis) in rats is precise. • Full functional recovery after crush is not achieved. • Functional deficits are associated with deficient synaptic inputs to motoneurons.
ISSN:0306-4522
1873-7544
DOI:10.1016/j.neuroscience.2013.06.019