Neuroprotective efficacy of subcutaneous insulin-like growth factor-I administration in normotensive and hypertensive rats with an ischemic stroke

• Published in: Neuroscience 2013-10, Vol.250, p.253-262
• Main Authors: De Geyter, D, Stoop, W, Sarre, S, De Keyser, J, Kooijman, R
• Format: Article
• Language: English
• Subjects: Animals; Biological and medical sciences; Body Weight - drug effects; brain ischemia; Brain Ischemia - drug therapy; Brain Ischemia - pathology; endothelin-1; Endothelin-1 - pharmacology; Fundamental and applied biological sciences. Psychology; Glial Fibrillary Acidic Protein - metabolism; Glucose - metabolism; Humans; hypertension; Hypertension - drug therapy; Hypertension - pathology; IGF-I; Immunohistochemistry; Injections, Subcutaneous; Insulin-Like Growth Factor I - administration & dosage; Insulin-Like Growth Factor I - pharmacology; Laser-Doppler Flowmetry; Macrophage Activation - drug effects; Male; Medical sciences; Microglia - drug effects; Nervous System Diseases - physiopathology; Nervous System Diseases - psychology; neuroglia; Neurology; Neuroprotective Agents; Rats; Rats, Inbred SHR; Rats, Inbred WKY; Recombinant Proteins - pharmacology; Stroke - drug therapy; Stroke - etiology; Stroke - pathology; Telemetry; Vascular diseases and vascular malformations of the nervous system; Vertebrates: nervous system and sense organs
• ISSN: 0306-4522; 1873-7544
• DOI: 10.1016/j.neuroscience.2013.07.016

Highlights • Systemic injection of IGF-I is neuroprotective in rats with ischemic stroke. • The neuroprotective effect of IGF-I is not mediated by the modulation of blood flow. • IGF-I is less effective in hypertensive rats than in normotensive controls. • IGF-I inhibits microglial activation in hypertensive rats but not in control rats.