Hypertonicity increases NO production to modulate the firing rate of magnocellular neurons of the supraoptic nucleus of rats

Highlights • Magnocellular neurons respond to hypertonicity by increasing nitric oxide (NO). • NO modulates the excitability of magnocellular neurons by decreasing their firing rate. • NO acts by hyperpolarizing the resting membrane potential of magnocellular neurons. • Modulation affects both the a...

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Bibliographic Details
Published in:Neuroscience 2013-10, Vol.250, p.70-79
Main Authors: da Silva, M.P, Ventura, R.R, Varanda, W.A
Format: Article
Language:English
Subjects:
Action Potentials - drug effects
Action Potentials - physiology
Animals
Arginine - pharmacology
Basal Nucleus of Meynert - cytology
Basal Nucleus of Meynert - metabolism
Electrophysiological Phenomena - physiology
electrophysiology
Enzyme Inhibitors - pharmacology
extracellular tonicity
Hypertonic Solutions - pharmacology
Hypotonic Solutions - pharmacology
In Vitro Techniques
Kinetics
magnocellular neurons
Neurology
Neurons - metabolism
NG-Nitroarginine Methyl Ester - pharmacology
nitric oxide
Nitric Oxide - biosynthesis
Nitric Oxide Synthase - antagonists & inhibitors
Osmolar Concentration
Patch-Clamp Techniques
Rats
Rats, Wistar
supraoptic nucleus
Supraoptic Nucleus - cytology
Supraoptic Nucleus - metabolism
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Summary:Highlights • Magnocellular neurons respond to hypertonicity by increasing nitric oxide (NO). • NO modulates the excitability of magnocellular neurons by decreasing their firing rate. • NO acts by hyperpolarizing the resting membrane potential of magnocellular neurons. • Modulation affects both the after-hyperpolarizing and after-depolarizing potential kinetics.
ISSN:0306-4522
1873-7544
DOI:10.1016/j.neuroscience.2013.06.067