Effects of IV iron isomaltoside-1000 treatment on regional brain iron status in an iron-deficient animal

Highlights • Murine extra-cellular ventral midbrain (VMB)-free iron increases by 50% in circadian light periods. • Iron-deprived (ID) mice VMB-free iron increased in 3 hours then normalized in 12 h after IV iron. • IV iron increased iron for 10 days in ID mice VMB and nucleus accumbens but not in ot...

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Bibliographic Details
Published in:Neuroscience 2013-08, Vol.246, p.179-185
Main Authors: Unger, E.L, Earley, C.J, Thomsen, L.L, Jones, B.C, Allen, R.P
Format: Article
Language:English
Subjects:
Anemia, Iron-Deficiency - drug therapy
Anemia, Iron-Deficiency - metabolism
Animals
Biological and medical sciences
Brain - drug effects
Brain - metabolism
Chronobiology
circadian brain iron
Disaccharides - pharmacology
Disaccharides - therapeutic use
Female
Ferric Compounds - pharmacology
Ferric Compounds - therapeutic use
Fundamental and applied biological sciences. Psychology
intravenous iron isomaltoside 1000
Iron - metabolism
Mice
microdialysis
Microdialysis - methods
Neurology
regional brain iron
restless legs syndrome
Treatment Outcome
Vertebrates: anatomy and physiology, studies on body, several organs or systems
Vertebrates: nervous system and sense organs
Willis-Ekbom disease
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Summary:Highlights • Murine extra-cellular ventral midbrain (VMB)-free iron increases by 50% in circadian light periods. • Iron-deprived (ID) mice VMB-free iron increased in 3 hours then normalized in 12 h after IV iron. • IV iron increased iron for 10 days in ID mice VMB and nucleus accumbens but not in other brain regions. • IV iron isomaltoside 1000 corrects ID seen in RLS without an indication of brain iron overload. • This is a pre-clinical model for IV iron treatments for RLS and other brain ID conditions.
ISSN:0306-4522
1873-7544
DOI:10.1016/j.neuroscience.2013.04.049