In vivo analysis of kallikrein-related peptidase 6 (KLK6) function in oligodendrocyte development and the expression of myelin proteins

Highlights ► KLK6−/− mice have fewer oligodendrocytes than WT mice in the developing spinal cord. ► KLK6−/− mice have lower amounts of myelin proteins in the developing spinal cord. ► KLK6−/− mice have lower amounts of myelin proteins in the damaged spinal cord. ► KLK6 is related to oligodendrocyte...

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Bibliographic Details
Published in:Neuroscience 2013-04, Vol.236, p.1-11
Main Authors: Murakami, K, Jiang, Y.-P, Tanaka, T, Bando, Y, Mitrovic, B, Yoshida, S
Format: Article
Language:English
Subjects:
Animals
Biological and medical sciences
Blotting, Western
Cell Differentiation
development
Disease Models, Animal
Fundamental and applied biological sciences. Psychology
Immunohistochemistry
Kallikreins - metabolism
Male
Mice
Mice, Inbred C57BL
Mice, Knockout
myelin
Myelin Proteins - biosynthesis
Neurology
Oligodendroglia - cytology
Oligodendroglia - metabolism
protease
Reverse Transcriptase Polymerase Chain Reaction
spinal cord
Spinal Cord - cytology
Spinal Cord - metabolism
Spinal Cord Injuries - metabolism
spinal cord injury
Vertebrates: nervous system and sense organs
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Summary:Highlights ► KLK6−/− mice have fewer oligodendrocytes than WT mice in the developing spinal cord. ► KLK6−/− mice have lower amounts of myelin proteins in the developing spinal cord. ► KLK6−/− mice have lower amounts of myelin proteins in the damaged spinal cord. ► KLK6 is related to oligodendrocyte development and myelin formation.
ISSN:0306-4522
1873-7544
DOI:10.1016/j.neuroscience.2012.12.073