γ-Hydroxybutyric acid induces actions via the GABAB receptor in arousal and motor control-related nuclei: Implications for therapeutic actions in behavioral state disorders

Highlights • GHB induces rises in calcium in LDT and DR neurons. • GHB inhibits cholinergic and serotonergic DR neurons. • Inhibition is via activation of the GABAB receptor.

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Bibliographic Details
Published in:Neuroscience 2013-09, Vol.248, p.261-277
Main Authors: Kohlmeier, K.A, Vardar, B, Christensen, M.H
Format: Article
Language:English
Subjects:
Animals
Arousal - drug effects
baclofen
Behavior, Animal - drug effects
Biological and medical sciences
Calcium - metabolism
Cholinergic Neurons - metabolism
Dorsal Raphe Nucleus - cytology
Electrophysiology
Fundamental and applied biological sciences. Psychology
GABA
Hydroxybutyrates - pharmacology
Inhibitory Postsynaptic Potentials - drug effects
Mice
Motor Activity - drug effects
motor atonia
Motor control and motor pathways. Reflexes. Control centers of vegetative functions. Vestibular system and equilibration
narcolepsy
Nerve Net - metabolism
Neural Pathways - metabolism
Neurology
Neurons - drug effects
Neurons - metabolism
Patch-Clamp Techniques - methods
Receptors, GABA-B - metabolism
REM sleep
Serotonergic Neurons - metabolism
Sleep. Vigilance
Tegmentum Mesencephali - cytology
Vertebrates: nervous system and sense organs
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Description
Summary:Highlights • GHB induces rises in calcium in LDT and DR neurons. • GHB inhibits cholinergic and serotonergic DR neurons. • Inhibition is via activation of the GABAB receptor.
ISSN:0306-4522
1873-7544
DOI:10.1016/j.neuroscience.2013.06.011