A neuregulin 1 transmembrane domain mutation causes imbalanced glutamatergic and dopaminergic receptor expression in mice

Highlights • NMDAR levels were increased in the cortex and nucleus accumbens of Nrg1+/− mice. • NMDAR levels were reduced in the thalamus of Nrg1+/− mice. • Nrg1+/− mice showed reduced striatal D2 receptor levels. • M1/4 and CB1 receptors remained largely unaltered in Nrg1+/− mice.

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Bibliographic Details
Published in:Neuroscience 2013-09, Vol.248, p.670-680
Main Authors: Newell, K.A, Karl, T, Huang, X.-F
Format: Article
Language:English
Subjects:
Adult and adolescent clinical studies
Animals
Biological and medical sciences
CB1 receptor
D2 receptor
Male
Medical sciences
Mice
mouse
Mutation
neuregulin
Neuregulin-1 - genetics
Neuregulin-1 - physiology
Neurology
Neuropharmacology
NMDA receptor
Pharmacology. Drug treatments
Protein Structure, Tertiary
Psychodysleptics: hallucinogen
Psychology. Psychoanalysis. Psychiatry
Psychopathology. Psychiatry
Psychopharmacology
Psychoses
Receptor, Cannabinoid, CB1 - analysis
Receptors, Dopamine - analysis
Receptors, Muscarinic - analysis
Receptors, N-Methyl-D-Aspartate - analysis
Schizophrenia
Schizophrenia - genetics
Schizophrenia - physiopathology
Synaptic Transmission - physiology
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Description
Summary:Highlights • NMDAR levels were increased in the cortex and nucleus accumbens of Nrg1+/− mice. • NMDAR levels were reduced in the thalamus of Nrg1+/− mice. • Nrg1+/− mice showed reduced striatal D2 receptor levels. • M1/4 and CB1 receptors remained largely unaltered in Nrg1+/− mice.
ISSN:0306-4522
1873-7544
DOI:10.1016/j.neuroscience.2013.06.037