Montreal Cognitive Assessment for the screening and prediction of cognitive decline in early Parkinson's disease

Abstract Background Early diagnosis of cognitive impairment in PD would allow appropriate monitoring and timely intervention to reduce the progression to dementia (PDD). Objective To study the usefulness of the Montreal Cognitive Assessment (MoCA) in the screening for mild cognitive impairment (PD-M...

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Bibliographic Details
Published in:Parkinsonism & related disorders 2014-11, Vol.20 (11), p.1145-1148
Main Authors: Kandiah, Nagaendran, Zhang, Angeline, Cenina, Alvin Rae, Au, Wing Lok, Nadkarni, Nivedita, Tan, Louis Cs
Format: Article
Language:English
Subjects:
Aged
Cognition Disorders - diagnosis
Cognition Disorders - etiology
Cognitive functions
Cross-Sectional Studies
Dementia
Female
Humans
Longitudinal Studies
Male
Mass Screening
Middle Aged
Neurology
Neuropsychological Tests
Parkinson Disease - complications
Parkinson's disease
Predictive Value of Tests
ROC Curve
Sensitivity and Specificity
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Summary:Abstract Background Early diagnosis of cognitive impairment in PD would allow appropriate monitoring and timely intervention to reduce the progression to dementia (PDD). Objective To study the usefulness of the Montreal Cognitive Assessment (MoCA) in the screening for mild cognitive impairment (PD-MCI) and its predictive utility in determining longitudinal cognitive decline in PD. Methods Prospective longitudinal study of patients with mild PD. PD-MCI and PDD was diagnosed based on the Movement Disorder taskforce (MDS) criteria. Receiver Operating Characteristic analyses and Cox regression analyses were performed. Results 95 patients; mean age 66.37 (SD 7.86); mean H&Y score of 1.99 (SD 0.45) were studied. At baseline, 34 patients fulfilled the MDS criteria for PD-MCI. MoCA, compared to the MMSE had a high discriminatory power in detecting PD-MCI [Area Under Curve (AUC) of 0.912, p  
ISSN:1353-8020
1873-5126
DOI:10.1016/j.parkreldis.2014.08.002