Helicobacter pylori detected in pharyngeal and laryngeal pathologies in patients with proven gastric colonization

Background Helicobacter pylori is known to cause gastric cancer. Presence and carcinogenicity in the upper aerodigestive system is doubtful. This study examined the prevalence of Helicobacter pylori and related factors in biopsies from the upper aerodigestive tract (UADT) in patients with gastric co...

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Published in:Head & neck 2014-11, Vol.36 (11), p.1562-1566
Main Authors: Fellmann, Jonas, Weisert, Jan U., Soltermann, Alex, Morand, Grégoire, Morra, Laura, Moch, Holger, Huber, Gerhard F., Probst, Rudolf
Format: Article
Language:English
Subjects:
Adult
Aged
Biopsy, Needle
Databases, Factual
Diagnosis, Differential
DNA, Bacterial - analysis
Female
Helicobacter Infections - epidemiology
Helicobacter Infections - pathology
Helicobacter pylori
Helicobacter pylori - isolation & purification
Humans
Laryngeal Diseases - microbiology
Laryngeal Diseases - pathology
larynx
Larynx - microbiology
Larynx - pathology
Male
Middle Aged
oral cavity
Pharyngeal Diseases - microbiology
Pharyngeal Diseases - pathology
pharynx
Pharynx - microbiology
Pharynx - pathology
polymerase chain reaction
Polymerase Chain Reaction - methods
Retrospective Studies
Sampling Studies
Statistics, Nonparametric
Stomach Neoplasms - microbiology
Stomach Neoplasms - pathology
Switzerland
Tissue Culture Techniques
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Summary:Background Helicobacter pylori is known to cause gastric cancer. Presence and carcinogenicity in the upper aerodigestive system is doubtful. This study examined the prevalence of Helicobacter pylori and related factors in biopsies from the upper aerodigestive tract (UADT) in patients with gastric colonization by Helicobacter pylori. Methods In a case series study, 26 patients with histopathologically confirmed gastric colonization were identified. A polymerase chain reaction (PCR) was performed on matched formalin‐fixed and paraffin‐embedded tissues of the stomach and the oral cavity, pharynx, or larynx. Results Helicobacter pylori was found in 38% of the samples from the oral cavity, pharynx, and larynx. An association with malignancies in these regions or possible risk factors, such as age, smoking, or alcohol, was not found. Conclusion The upper aerodigestive system seems to be an additional reservoir in a significant percentage of patients presenting with Helicobacter pylori gastritis. © 2013 Wiley Periodicals, Inc. Head Neck 36: 1562–1566, 2014
ISSN:1043-3074
1097-0347
DOI:10.1002/hed.23492