Suppression of outward K+ currents by WIN55212-2 in rat retinal ganglion cells is independent of CB1/CB2 receptors

Highlights • WIN dose-dependently inhibits outward K+ currents of rat retinal ganglion cells. • AEA suppresses outward K+ currents of rat retinal ganglion cells. • WIN mainly suppresses TEA-sensitive K+ currents of rat retinal ganglion cells. • The effects of WIN55212-2 and AEA are not mediated by C...

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Bibliographic Details
Published in:Neuroscience 2013-12, Vol.253, p.183-193
Main Authors: Zhang, C.-Q, Wu, H.-J, Wang, S.-Y, Yin, S, Lu, X.-J, Miao, Y, Wang, X.-H, Yang, X.-L, Wang, Z
Format: Article
Language:English
Subjects:
Action Potentials - drug effects
Adenosine Triphosphate - pharmacology
anandamide
Animals
Benzoxazines - pharmacology
Biological and medical sciences
Calcium Channel Blockers - pharmacology
cannabinoid receptor
Cannabinoid Receptor Agonists - pharmacology
CB1/CB2 receptor agonist
Dose-Response Relationship, Drug
Eye and associated structures. Visual pathways and centers. Vision
Fundamental and applied biological sciences. Psychology
In Vitro Techniques
Inhibitory Concentration 50
Male
Medical sciences
Morpholines - pharmacology
Naphthalenes - pharmacology
Neurology
Neuropharmacology
patch-clamp
Pharmacology. Drug treatments
Piperidines - pharmacology
Potassium Channel Blockers - pharmacology
Potassium Channels - physiology
Psychodysleptics: hallucinogen
Psychology. Psychoanalysis. Psychiatry
Psychopharmacology
Pyrazoles - pharmacology
Rats
Rats, Sprague-Dawley
Receptors, Cannabinoid - metabolism
Retina - cytology
Retinal Ganglion Cells - drug effects
Rhodamines - pharmacokinetics
TEA-sensitive K+ current
Vertebrates: nervous system and sense organs
Visual Pathways - drug effects
Visual Pathways - physiology
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Summary:Highlights • WIN dose-dependently inhibits outward K+ currents of rat retinal ganglion cells. • AEA suppresses outward K+ currents of rat retinal ganglion cells. • WIN mainly suppresses TEA-sensitive K+ currents of rat retinal ganglion cells. • The effects of WIN55212-2 and AEA are not mediated by CB1R/CB2R.
ISSN:0306-4522
1873-7544
DOI:10.1016/j.neuroscience.2013.08.056