Long non-coding RNAs in colorectal cancer: implications for pathogenesis and clinical application

Long non-coding RNAs (lncRNAs) are a class of newly identified non-coding RNA molecules that are emerging as key regulators of tumor initiation and development. Colorectal cancer (CRC) remains a major health problem worldwide, and there remains a need to further refine the current screening approach...

Full description

Saved in:
Bibliographic Details
Published in:Modern pathology 2014-10, Vol.27 (10), p.1310-1320
Main Authors: Xu, Mi-die, Qi, Peng, Du, Xiang
Format: Article
Language:English
Subjects:
631/337/384/2568
692/420/755
692/53/2421
692/699/67/1504/1885
Animals
Apoptosis
Cell growth
Colorectal cancer
Colorectal Neoplasms - genetics
diagnosis
dysregulation
Genomes
Humans
Laboratory Medicine
long non-coding RNA
Medical prognosis
Medicine
Medicine & Public Health
Metastasis
MicroRNAs
Pathogenesis
Pathology
Physiology
prognosis
review-article
RNA polymerase
RNA, Long Noncoding - genetics
Tumorigenesis
Tumors
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Long non-coding RNAs (lncRNAs) are a class of newly identified non-coding RNA molecules that are emerging as key regulators of tumor initiation and development. Colorectal cancer (CRC) remains a major health problem worldwide, and there remains a need to further refine the current screening approaches as well as provide tailored diagnostic and therapeutic approaches. Multiple dysregulated lncRNAs participate in tumorigenesis through a variety of molecular mechanisms, and various regulatory factors frequently contribute to the aberrant expression of lncRNAs in CRC, thereby allowing malignant transformation. Additionally, the association of dysregulated lncRNAs with specific developmental stages and clinical outcomes indicates their potential as strong diagnostic and prognostic predictors as well as therapeutic targets. Here we provide a brief overview of the known functions of CRC-associated lncRNAs, describe some potential molecular mechanisms that underlie changes in lncRNA expression in CRC, and attempt to uncover their clinical and therapeutic potential.
ISSN:0893-3952
1530-0285
DOI:10.1038/modpathol.2014.33