Resveratrol and its oligomers: modulation of sphingolipid metabolism and signaling in disease

Resveratrol, a natural compound endowed with multiple health-promoting effects, has received much attention given its potential for the treatment of cardiovascular, inflammatory, neurodegenerative, metabolic and age-related diseases. However, the translational potential of resveratrol has been limit...

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Bibliographic Details
Published in:Archives of toxicology 2014-12, Vol.88 (12), p.2213-2232
Main Authors: Lim, Keng Gat, Gray, Alexander I., Anthony, Nahoum G., Mackay, Simon P., Pyne, Susan, Pyne, Nigel J.
Format: Article
Language:English
Subjects:
Animals
Antineoplastic Agents, Phytogenic - chemistry
Antineoplastic Agents, Phytogenic - pharmacokinetics
Antineoplastic Agents, Phytogenic - therapeutic use
Antineoplastic Agents, Phytogenic - toxicity
Apoptosis - drug effects
Binding Sites
Bioavailability
Biomedical and Life Sciences
Biomedicine
Cardiovascular Diseases - drug therapy
Cardiovascular Diseases - metabolism
Cardiovascular Diseases - pathology
Dietary supplements
Disease
Drug Discovery
Environmental Health
Humans
Metabolism
Molecular Docking Simulation
Molecular Structure
Neoplasms - drug therapy
Neoplasms - metabolism
Neoplasms - pathology
Neurodegenerative Diseases - drug therapy
Neurodegenerative Diseases - metabolism
Neurodegenerative Diseases - pathology
Occupational Medicine/Industrial Medicine
Pharmacology/Toxicology
Review Article
Signal Transduction
Sphingolipids - metabolism
Stilbenes - chemistry
Stilbenes - pharmacokinetics
Stilbenes - therapeutic use
Stilbenes - toxicity
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Summary:Resveratrol, a natural compound endowed with multiple health-promoting effects, has received much attention given its potential for the treatment of cardiovascular, inflammatory, neurodegenerative, metabolic and age-related diseases. However, the translational potential of resveratrol has been limited by its specificity, poor bioavailability and uncertain toxicity. In recent years, there has been an accumulation of evidence demonstrating that resveratrol modulates sphingolipid metabolism. Moreover, resveratrol forms higher order oligomers that exhibit better selectivity and potency in modulating sphingolipid metabolism. This review evaluates the evidence supporting the modulation of sphingolipid metabolism and signaling as a mechanism of action underlying the therapeutic efficacy of resveratrol and oligomers in diseases, such as cancer.
ISSN:0340-5761
1432-0738
DOI:10.1007/s00204-014-1386-4