Involvement of the spinal NALP1 inflammasome in neuropathic pain and aspirin-triggered-15-epi-lipoxin A4 induced analgesia

Highlights • NALP1 inflammasome platform was activated in the spinal cord of CCI rats. • CCI-induced NALP1 inflammasome was located in spinal neurons and astrocytes. • ATL relieved the CCI-induced neuropathic pain behaviors. • ATL inhibited the CCI-induced activation of the NALP1 inflammasome....

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Bibliographic Details
Published in:Neuroscience 2013-12, Vol.254, p.230-240
Main Authors: Li, Q, Tian, Y, Wang, Z.-F, Liu, S.-B, Mi, W.-L, Ma, H.-J, Wu, G.-C, Wang, J, Yu, J, Wang, Y.-Q
Format: Article
Language:English
Subjects:
Analgesia - methods
Animals
Aspirin - administration & dosage
aspirin-triggered-15-epi-lipoxin A4
Biological and medical sciences
caspase
Chronic Disease
Drug Therapy, Combination
Fundamental and applied biological sciences. Psychology
Inflammasomes - biosynthesis
Injections, Spinal
interleukin
Lipoxins - administration & dosage
Male
Medical sciences
NALP1 inflammasome
Nerve Tissue Proteins - biosynthesis
Nervous system involvement in other diseases. Miscellaneous
Neuralgia - drug therapy
Neuralgia - metabolism
Neurology
neuropathic pain
Rats
Rats, Sprague-Dawley
Spinal Cord - drug effects
Spinal Cord - metabolism
Vertebrates: nervous system and sense organs
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Summary:Highlights • NALP1 inflammasome platform was activated in the spinal cord of CCI rats. • CCI-induced NALP1 inflammasome was located in spinal neurons and astrocytes. • ATL relieved the CCI-induced neuropathic pain behaviors. • ATL inhibited the CCI-induced activation of the NALP1 inflammasome.
ISSN:0306-4522
1873-7544
DOI:10.1016/j.neuroscience.2013.09.028