Bidirectional modulation of hippocampal gamma (20–80 Hz) frequency activity in vitro via alpha(α)- and beta(β)-adrenergic receptors (AR)

Highlights • Noradrenaline causes a reduction in gamma frequency oscillations in the hippocampus in vitro. • Noradrenaline causes a reduction in IPSPs and EPSPs during gamma frequency activity. • Activation of alpha-adrenergic 1 receptors reduces gamma frequency activity. • Activation of beta-adrene...

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Bibliographic Details
Published in:Neuroscience 2013-12, Vol.253, p.142-154
Main Authors: Haggerty, D.C, Glykos, V, Adams, N.E, LeBeau, F.E.N
Format: Article
Language:English
Subjects:
Action Potentials - drug effects
Action Potentials - physiology
Adrenergic Agents - pharmacology
Analysis of Variance
Animals
Biological and medical sciences
Biophysics
Drug Interactions
Electric Stimulation
Excitatory Amino Acid Agonists - pharmacology
Fourier Analysis
Fundamental and applied biological sciences. Psychology
gamma oscillation
hippocampus
Hippocampus - drug effects
Hippocampus - physiology
In Vitro Techniques
Inhibitory Postsynaptic Potentials - drug effects
Kainic Acid - pharmacology
Male
Neurology
noradrenaline
Periodicity
rat
Rats
Rats, Wistar
Receptors, Adrenergic, alpha - metabolism
Receptors, Adrenergic, beta - metabolism
Time Factors
Vertebrates: nervous system and sense organs
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Summary:Highlights • Noradrenaline causes a reduction in gamma frequency oscillations in the hippocampus in vitro. • Noradrenaline causes a reduction in IPSPs and EPSPs during gamma frequency activity. • Activation of alpha-adrenergic 1 receptors reduces gamma frequency activity. • Activation of beta-adrenergic 1 receptors increases gamma frequency activity. • Noradrenaline can bidirectionally modulate network gamma oscillations via activation of different receptor subtypes.
ISSN:0306-4522
1873-7544
DOI:10.1016/j.neuroscience.2013.08.028