Prenylated Indole Alkaloid Derivatives from Marine Sediment-Derived Fungus Penicillium paneum SD-44

Three new prenylated indole alkaloids, including two β‐carbolines, penipalines A and B (1 and 2, resp.), and one indole carbaldehyde derivative, penipaline C (3), as well as two known indole derived analogs, 4 and 5, were isolated from the deep‐sea‐sediment derived fungus Penicillium paneum SD‐44 cu...

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Bibliographic Details
Published in:Helvetica chimica acta 2014-10, Vol.97 (10), p.1440-1444
Main Authors: Li, Chun-Shun, Li, Xiao-Ming, An, Chun-Yan, Wang, Bin-Gui
Format: Article
Language:English
Subjects:
Alkaloids
Indole alkaloids
Penicillium
Penicillium paneum
β-Carbolines
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Summary:Three new prenylated indole alkaloids, including two β‐carbolines, penipalines A and B (1 and 2, resp.), and one indole carbaldehyde derivative, penipaline C (3), as well as two known indole derived analogs, 4 and 5, were isolated from the deep‐sea‐sediment derived fungus Penicillium paneum SD‐44 cultured in a 500‐l bioreactor. The structures of the new compounds were determined on the basis of 1D‐ and 2D‐NMR spectroscopy, as well as by high‐resolution mass spectrometry. The new compounds 2 and 3 showed potent cytotoxic activities against A‐549 and HCT‐116 cell lines.
ISSN:0018-019X
1522-2675
DOI:10.1002/hlca.201400035