Acute binge pattern cocaine administration induces region-specific effects in D1-r- and D2-r-expressing cells in eGFP transgenic mice

• Published in: Neuroscience 2013-12, Vol.253, p.123-131
• Main Authors: Lawhorn, C, Edusei, E, Zhou, Y, Ho, A, Kreek, M.J
• Format: Article
• Language: English
• Subjects: addiction; Analysis of Variance; Animals; Biological and medical sciences; Cell Count; cocaine; Cocaine - administration & dosage; Cocaine - pharmacology; Cocaine-Related Disorders - metabolism; Cocaine-Related Disorders - pathology; Corpus Striatum - drug effects; Corpus Striatum - metabolism; Corpus Striatum - pathology; dopamine; Dopamine Uptake Inhibitors - administration & dosage; Dopamine Uptake Inhibitors - pharmacology; eGFP; Fundamental and applied biological sciences. Psychology; Green Fluorescent Proteins - genetics; Medical sciences; Mice; Mice, Inbred C57BL; Mice, Transgenic; Microscopy, Confocal; Neurology; Neuropharmacology; Nucleus Accumbens - cytology; Nucleus Accumbens - drug effects; Nucleus Accumbens - metabolism; Pharmacology. Drug treatments; Psychoanaleptics: cns stimulant, antidepressant agent, nootropic agent, mood stabilizer; Psychoanaleptics: cns stimulant, antidepressant agent, nootropic agent, mood stabilizer..., (alzheimer disease); Psychology. Psychoanalysis. Psychiatry; Psychopharmacology; Receptors, Dopamine D1 - genetics; Receptors, Dopamine D1 - metabolism; Receptors, Dopamine D2 - genetics; Receptors, Dopamine D2 - metabolism; stereology; striatum; Time Factors; Vertebrates: nervous system and sense organs
• ISSN: 0306-4522; 1873-7544
• DOI: 10.1016/j.neuroscience.2013.08.032

Highlights • Acute binge-pattern cocaine-induced region-specific effects in the striatum. • Cell counts revealed differential patterns in D1-r versus D2-r labeled cells. • Drd1 -eGFP mice had more labeled cells in the dorsolateral striatum. • Drd2 -eGFP mice had fewer labeled cells in the dorsolateral striatum. • Drd2 -eGFP mice also showed fewer labeled cells in the NAc core.