Effects of chronic exercise and treatment with the antipsychotic drug olanzapine on hippocampal volume in adult female rats

Highlights • Chronic olanzapine decreases hippocampal volume in sedentary rats. • Exercise increases hippocampal volume in olanzapine-treated rats. • Volumetric changes significant in dentate gyrus and CA1 sub-regions only. • Hippocampal volume smaller in rats with olanzapine-induced glucose intoler...

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Bibliographic Details
Published in:Neuroscience 2013-12, Vol.255, p.147-157
Main Authors: Barr, A.M, Wu, C.H, Wong, C, Hercher, C, Töpfer, E, Boyda, H.N, Procyshyn, R.M, Honer, W.G, Beasley, C.L
Format: Article
Language:English
Subjects:
Aging
Animals
Antipsychotic Agents - pharmacology
Benzodiazepines - pharmacology
Biological and medical sciences
CA1
dentate gyrus
Female
Fundamental and applied biological sciences. Psychology
glucose intolerance
Hippocampus - drug effects
Medical sciences
Neurology
Neuropharmacology
Pharmacology. Drug treatments
Physical Conditioning, Animal
Psycholeptics: tranquillizer, neuroleptic
Psychology. Psychoanalysis. Psychiatry
Psychopharmacology
Rats
Rats, Sprague-Dawley
second generation antipsychotic
stereology
Vertebrates: nervous system and sense organs
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Summary:Highlights • Chronic olanzapine decreases hippocampal volume in sedentary rats. • Exercise increases hippocampal volume in olanzapine-treated rats. • Volumetric changes significant in dentate gyrus and CA1 sub-regions only. • Hippocampal volume smaller in rats with olanzapine-induced glucose intolerance.
ISSN:0306-4522
1873-7544
DOI:10.1016/j.neuroscience.2013.10.010