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Anorexia: an early sign of fourth ventricle astrocytoma in children
Introduction Paediatric low-grade astrocytomas of the fourth ventricle are rare tumours, generally revealed by hydrocephalus. However, some patients present with a history of severe anorexia. It might be a harbinger, which if recognized, could lead to earlier diagnosis. We decided to examine our dat...
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| Published in: | Child's nervous system 2014-12, Vol.30 (12), p.2089-2095 |
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| creator | Leroy, Henri-Arthur Baroncini, Marc Delestret, Isabelle Florent, Vincent Vinchon, Matthieu |
| description | Introduction
Paediatric low-grade astrocytomas of the fourth ventricle are rare tumours, generally revealed by hydrocephalus. However, some patients present with a history of severe anorexia. It might be a harbinger, which if recognized, could lead to earlier diagnosis. We decided to examine our database in order to evaluate the incidence and signification of anorexia in this context.
Methods
Retrospective monocentric study of cases of low-grade astrocytomas of the fourth ventricle operated between 1991 and 2012 in our paediatric neurosurgery department. We particularly observed the clinical presentation and long-term clinical, oncological and radiological evolution. Non-parametrical tests were used (Mann–Whitney, Fisher).
Results
We reviewed 34 cases, 31 pilocytic astrocytomas and 3 diffuse astrocytomas, 16 boys and 18 girls, (M/F ratio 0.89). Mean age at diagnosis was 8 years old. Seven presented with notable anorexia, the average BMI in this group was ≤2 standard deviation (SD); with clinical signs evolving for 11.5 months. Twenty-seven children had no anorexia; average BMI in this group was +1 SD, with clinical evolution for 6 months on an average of
p
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| doi_str_mv | 10.1007/s00381-014-2533-1 |
| format | article |
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Paediatric low-grade astrocytomas of the fourth ventricle are rare tumours, generally revealed by hydrocephalus. However, some patients present with a history of severe anorexia. It might be a harbinger, which if recognized, could lead to earlier diagnosis. We decided to examine our database in order to evaluate the incidence and signification of anorexia in this context.
Methods
Retrospective monocentric study of cases of low-grade astrocytomas of the fourth ventricle operated between 1991 and 2012 in our paediatric neurosurgery department. We particularly observed the clinical presentation and long-term clinical, oncological and radiological evolution. Non-parametrical tests were used (Mann–Whitney, Fisher).
Results
We reviewed 34 cases, 31 pilocytic astrocytomas and 3 diffuse astrocytomas, 16 boys and 18 girls, (M/F ratio 0.89). Mean age at diagnosis was 8 years old. Seven presented with notable anorexia, the average BMI in this group was ≤2 standard deviation (SD); with clinical signs evolving for 11.5 months. Twenty-seven children had no anorexia; average BMI in this group was +1 SD, with clinical evolution for 6 months on an average of
p
< 0.05. We found no significant difference regarding hydrocephalus or tumour location. In all children with anorexia, body mass index improved markedly in the postoperative follow-up, which lasted, on average, for 6 years.
Conclusion
Anorexia with stunted body weight curve is a non-exceptional presentation in children with low-grade astrocytomas of the fourth ventricle. Unexplained or atypical anorexia with negative etiologic assessment should prompt cerebral imaging. Clinical improvement after surgical resection, could suggest a possible interaction between tumour tissue and appetite-suppressing peptide secretion.</description><identifier>ISSN: 0256-7040</identifier><identifier>EISSN: 1433-0350</identifier><identifier>DOI: 10.1007/s00381-014-2533-1</identifier><identifier>PMID: 25142692</identifier><language>eng</language><publisher>Berlin/Heidelberg: Springer Berlin Heidelberg</publisher><subject>Adolescent ; Anorexia - epidemiology ; Anorexia - etiology ; Anorexia - surgery ; Body Weight ; Cerebral Ventricle Neoplasms - diagnosis ; Cerebral Ventricle Neoplasms - epidemiology ; Cerebral Ventricle Neoplasms - surgery ; Child ; Child, Preschool ; Early Diagnosis ; Female ; Fourth Ventricle - surgery ; Humans ; Incidence ; Infant ; Male ; Medicine ; Medicine & Public Health ; Neurologic Examination ; Neurosciences ; Neurosurgery ; Original Paper ; Retrospective Studies ; Statistics, Nonparametric</subject><ispartof>Child's nervous system, 2014-12, Vol.30 (12), p.2089-2095</ispartof><rights>Springer-Verlag Berlin Heidelberg 2014</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c447t-29fe3842890f4d8422e623b6a8b384fbe17b8a64ab9abd3620f1e2eed38a56a33</citedby><cites>FETCH-LOGICAL-c447t-29fe3842890f4d8422e623b6a8b384fbe17b8a64ab9abd3620f1e2eed38a56a33</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/25142692$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Leroy, Henri-Arthur</creatorcontrib><creatorcontrib>Baroncini, Marc</creatorcontrib><creatorcontrib>Delestret, Isabelle</creatorcontrib><creatorcontrib>Florent, Vincent</creatorcontrib><creatorcontrib>Vinchon, Matthieu</creatorcontrib><title>Anorexia: an early sign of fourth ventricle astrocytoma in children</title><title>Child's nervous system</title><addtitle>Childs Nerv Syst</addtitle><addtitle>Childs Nerv Syst</addtitle><description>Introduction
Paediatric low-grade astrocytomas of the fourth ventricle are rare tumours, generally revealed by hydrocephalus. However, some patients present with a history of severe anorexia. It might be a harbinger, which if recognized, could lead to earlier diagnosis. We decided to examine our database in order to evaluate the incidence and signification of anorexia in this context.
Methods
Retrospective monocentric study of cases of low-grade astrocytomas of the fourth ventricle operated between 1991 and 2012 in our paediatric neurosurgery department. We particularly observed the clinical presentation and long-term clinical, oncological and radiological evolution. Non-parametrical tests were used (Mann–Whitney, Fisher).
Results
We reviewed 34 cases, 31 pilocytic astrocytomas and 3 diffuse astrocytomas, 16 boys and 18 girls, (M/F ratio 0.89). Mean age at diagnosis was 8 years old. Seven presented with notable anorexia, the average BMI in this group was ≤2 standard deviation (SD); with clinical signs evolving for 11.5 months. Twenty-seven children had no anorexia; average BMI in this group was +1 SD, with clinical evolution for 6 months on an average of
p
< 0.05. We found no significant difference regarding hydrocephalus or tumour location. In all children with anorexia, body mass index improved markedly in the postoperative follow-up, which lasted, on average, for 6 years.
Conclusion
Anorexia with stunted body weight curve is a non-exceptional presentation in children with low-grade astrocytomas of the fourth ventricle. Unexplained or atypical anorexia with negative etiologic assessment should prompt cerebral imaging. Clinical improvement after surgical resection, could suggest a possible interaction between tumour tissue and appetite-suppressing peptide secretion.</description><subject>Adolescent</subject><subject>Anorexia - epidemiology</subject><subject>Anorexia - etiology</subject><subject>Anorexia - surgery</subject><subject>Body Weight</subject><subject>Cerebral Ventricle Neoplasms - diagnosis</subject><subject>Cerebral Ventricle Neoplasms - epidemiology</subject><subject>Cerebral Ventricle Neoplasms - surgery</subject><subject>Child</subject><subject>Child, Preschool</subject><subject>Early Diagnosis</subject><subject>Female</subject><subject>Fourth Ventricle - surgery</subject><subject>Humans</subject><subject>Incidence</subject><subject>Infant</subject><subject>Male</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Neurologic Examination</subject><subject>Neurosciences</subject><subject>Neurosurgery</subject><subject>Original Paper</subject><subject>Retrospective Studies</subject><subject>Statistics, Nonparametric</subject><issn>0256-7040</issn><issn>1433-0350</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2014</creationdate><recordtype>article</recordtype><recordid>eNqNkEtPwzAQhC0EoqXwA7ggH7kE1o84CTdU8ZIqcYGz5SSbNlViFztB9N_jqoUj4rSj3ZmR9iPkksENA8huA4DIWQJMJjwVImFHZMpkFCBSOCZT4KlKMpAwIWchrAFYmvPilEx4yiRXBZ-S-b11Hr9ac0eNpWh8t6WhXVrqGtq40Q8r-ol28G3VITVh8K7aDq43tLW0WrVd7dGek5PGdAEvDnNG3h8f3ubPyeL16WV-v0gqKbMh4UWDIpc8L6CRdRQcFRelMnkZ102JLCtzo6QpC1PWQnFoGHLEWuQmVUaIGbne9268-xgxDLpvQ4VdZyy6MWim4tuiUCD_YeUclBSwa2V7a-VdCB4bvfFtb_xWM9A7zHqPWUfMeodZs5i5OtSPZY_1b-KHazTwvSHEk12i1-sI00Y6f7R-Azqghro</recordid><startdate>20141201</startdate><enddate>20141201</enddate><creator>Leroy, Henri-Arthur</creator><creator>Baroncini, Marc</creator><creator>Delestret, Isabelle</creator><creator>Florent, Vincent</creator><creator>Vinchon, Matthieu</creator><general>Springer Berlin Heidelberg</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>7TK</scope></search><sort><creationdate>20141201</creationdate><title>Anorexia: an early sign of fourth ventricle astrocytoma in children</title><author>Leroy, Henri-Arthur ; Baroncini, Marc ; Delestret, Isabelle ; Florent, Vincent ; Vinchon, Matthieu</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c447t-29fe3842890f4d8422e623b6a8b384fbe17b8a64ab9abd3620f1e2eed38a56a33</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2014</creationdate><topic>Adolescent</topic><topic>Anorexia - epidemiology</topic><topic>Anorexia - etiology</topic><topic>Anorexia - surgery</topic><topic>Body Weight</topic><topic>Cerebral Ventricle Neoplasms - diagnosis</topic><topic>Cerebral Ventricle Neoplasms - epidemiology</topic><topic>Cerebral Ventricle Neoplasms - surgery</topic><topic>Child</topic><topic>Child, Preschool</topic><topic>Early Diagnosis</topic><topic>Female</topic><topic>Fourth Ventricle - surgery</topic><topic>Humans</topic><topic>Incidence</topic><topic>Infant</topic><topic>Male</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Neurologic Examination</topic><topic>Neurosciences</topic><topic>Neurosurgery</topic><topic>Original Paper</topic><topic>Retrospective Studies</topic><topic>Statistics, Nonparametric</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Leroy, Henri-Arthur</creatorcontrib><creatorcontrib>Baroncini, Marc</creatorcontrib><creatorcontrib>Delestret, Isabelle</creatorcontrib><creatorcontrib>Florent, Vincent</creatorcontrib><creatorcontrib>Vinchon, Matthieu</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>Neurosciences Abstracts</collection><jtitle>Child's nervous system</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Leroy, Henri-Arthur</au><au>Baroncini, Marc</au><au>Delestret, Isabelle</au><au>Florent, Vincent</au><au>Vinchon, Matthieu</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Anorexia: an early sign of fourth ventricle astrocytoma in children</atitle><jtitle>Child's nervous system</jtitle><stitle>Childs Nerv Syst</stitle><addtitle>Childs Nerv Syst</addtitle><date>2014-12-01</date><risdate>2014</risdate><volume>30</volume><issue>12</issue><spage>2089</spage><epage>2095</epage><pages>2089-2095</pages><issn>0256-7040</issn><eissn>1433-0350</eissn><abstract>Introduction
Paediatric low-grade astrocytomas of the fourth ventricle are rare tumours, generally revealed by hydrocephalus. However, some patients present with a history of severe anorexia. It might be a harbinger, which if recognized, could lead to earlier diagnosis. We decided to examine our database in order to evaluate the incidence and signification of anorexia in this context.
Methods
Retrospective monocentric study of cases of low-grade astrocytomas of the fourth ventricle operated between 1991 and 2012 in our paediatric neurosurgery department. We particularly observed the clinical presentation and long-term clinical, oncological and radiological evolution. Non-parametrical tests were used (Mann–Whitney, Fisher).
Results
We reviewed 34 cases, 31 pilocytic astrocytomas and 3 diffuse astrocytomas, 16 boys and 18 girls, (M/F ratio 0.89). Mean age at diagnosis was 8 years old. Seven presented with notable anorexia, the average BMI in this group was ≤2 standard deviation (SD); with clinical signs evolving for 11.5 months. Twenty-seven children had no anorexia; average BMI in this group was +1 SD, with clinical evolution for 6 months on an average of
p
< 0.05. We found no significant difference regarding hydrocephalus or tumour location. In all children with anorexia, body mass index improved markedly in the postoperative follow-up, which lasted, on average, for 6 years.
Conclusion
Anorexia with stunted body weight curve is a non-exceptional presentation in children with low-grade astrocytomas of the fourth ventricle. Unexplained or atypical anorexia with negative etiologic assessment should prompt cerebral imaging. Clinical improvement after surgical resection, could suggest a possible interaction between tumour tissue and appetite-suppressing peptide secretion.</abstract><cop>Berlin/Heidelberg</cop><pub>Springer Berlin Heidelberg</pub><pmid>25142692</pmid><doi>10.1007/s00381-014-2533-1</doi><tpages>7</tpages></addata></record> |
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| subjects | Adolescent Anorexia - epidemiology Anorexia - etiology Anorexia - surgery Body Weight Cerebral Ventricle Neoplasms - diagnosis Cerebral Ventricle Neoplasms - epidemiology Cerebral Ventricle Neoplasms - surgery Child Child, Preschool Early Diagnosis Female Fourth Ventricle - surgery Humans Incidence Infant Male Medicine Medicine & Public Health Neurologic Examination Neurosciences Neurosurgery Original Paper Retrospective Studies Statistics, Nonparametric |
| title | Anorexia: an early sign of fourth ventricle astrocytoma in children |
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