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Executive deficit in spinocerebellar ataxia type 2 is related to expanded CAG repeats: Evidence from antisaccadic eye movements
Although antisaccadic task is a sensitive research tool in psychopathology, it has not been systematically studied in patients with spinocerebellar ataxia type 2 (SCA2). To identify putative biomarkers of executive dysfunction in SCA2 we assessed the antisaccade performance in 41 SCA2 patients and t...
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Published in: | Brain and cognition 2014-11, Vol.91, p.28-34 |
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creator | Rodríguez-Labrada, Roberto Velázquez-Pérez, Luis Aguilera-Rodríguez, Raúl Seifried-Oberschmidt, Carola Peña-Acosta, Arnoy Canales-Ochoa, Nalia Medrano-Montero, Jacqueline Estupiñan-Rodríguez, Annelié Vázquez-Mojena, Yaimeé González-Zaldivar, Yanetza Laffita Mesa, Jose M. |
description | Although antisaccadic task is a sensitive research tool in psychopathology, it has not been systematically studied in patients with spinocerebellar ataxia type 2 (SCA2). To identify putative biomarkers of executive dysfunction in SCA2 we assessed the antisaccade performance in 41 SCA2 patients and their sex-and-age matched controls using an electronystagmography device. We studied the relationship between findings in the antisaccade task and CAG repeat length and motor function as assessed using the Scale for the Assessment and Rating of Ataxia (SARA), Nine-Hole Pegboard Test and a validated battery for executive dysfunctions. SCA2 patients showed a significant increase of inhibition and omission antisaccadic error rates, decrease of corrected antisaccadic errors and prolongation of antisaccadic latency and antisaccadic correction latency. Multiple regression predictions identified the expanded CAG repeat as a significant contributing factor on inhibition antisaccadic error rate and percentage of corrected antisaccadic errors. Impaired antisaccadic performance was associated to higher Stroop interference task and verbal fluency test deficits. In conclusion, antisaccadic eye movement abnormalities are a newly recognized association with the genetic abnormality in SCA2 and correlate with executive dysfunction in SCA2. Antisaccade parameters are a promising source of cognitive biomarkers for exploring the disease pathophysiology, and assessing the efficacy of therapeutic options. |
doi_str_mv | 10.1016/j.bandc.2014.07.007 |
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To identify putative biomarkers of executive dysfunction in SCA2 we assessed the antisaccade performance in 41 SCA2 patients and their sex-and-age matched controls using an electronystagmography device. We studied the relationship between findings in the antisaccade task and CAG repeat length and motor function as assessed using the Scale for the Assessment and Rating of Ataxia (SARA), Nine-Hole Pegboard Test and a validated battery for executive dysfunctions. SCA2 patients showed a significant increase of inhibition and omission antisaccadic error rates, decrease of corrected antisaccadic errors and prolongation of antisaccadic latency and antisaccadic correction latency. Multiple regression predictions identified the expanded CAG repeat as a significant contributing factor on inhibition antisaccadic error rate and percentage of corrected antisaccadic errors. Impaired antisaccadic performance was associated to higher Stroop interference task and verbal fluency test deficits. In conclusion, antisaccadic eye movement abnormalities are a newly recognized association with the genetic abnormality in SCA2 and correlate with executive dysfunction in SCA2. Antisaccade parameters are a promising source of cognitive biomarkers for exploring the disease pathophysiology, and assessing the efficacy of therapeutic options.</description><identifier>ISSN: 0278-2626</identifier><identifier>EISSN: 1090-2147</identifier><identifier>DOI: 10.1016/j.bandc.2014.07.007</identifier><identifier>PMID: 25189938</identifier><identifier>CODEN: BRCOEI</identifier><language>eng</language><publisher>Amsterdam: Elsevier Inc</publisher><subject>Adolescent ; Adult ; Adult and adolescent clinical studies ; Alleles ; Antisaccades ; Biological and medical sciences ; Biomarkers ; Biomarkers - analysis ; Brain Stem - physiopathology ; CAG repeats ; Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases ; Executive dysfunctions ; Female ; Gene Frequency - genetics ; Humans ; Male ; Medical sciences ; Middle Aged ; Neurology ; Organic mental disorders. Neuropsychology ; Psychology. Psychoanalysis. Psychiatry ; Psychopathology. Psychiatry ; Repetitive Sequences, Nucleic Acid ; Saccades ; Spinocerebellar ataxias ; Spinocerebellar Ataxias - genetics ; Young Adult</subject><ispartof>Brain and cognition, 2014-11, Vol.91, p.28-34</ispartof><rights>2014 Elsevier Inc.</rights><rights>2015 INIST-CNRS</rights><rights>Copyright © 2014 Elsevier Inc. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c422t-25bfefafb5c926ea104eef7c07487360850752c680b693d7ffc410c5e887d8f83</citedby><cites>FETCH-LOGICAL-c422t-25bfefafb5c926ea104eef7c07487360850752c680b693d7ffc410c5e887d8f83</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=29031500$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/25189938$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Rodríguez-Labrada, Roberto</creatorcontrib><creatorcontrib>Velázquez-Pérez, Luis</creatorcontrib><creatorcontrib>Aguilera-Rodríguez, Raúl</creatorcontrib><creatorcontrib>Seifried-Oberschmidt, Carola</creatorcontrib><creatorcontrib>Peña-Acosta, Arnoy</creatorcontrib><creatorcontrib>Canales-Ochoa, Nalia</creatorcontrib><creatorcontrib>Medrano-Montero, Jacqueline</creatorcontrib><creatorcontrib>Estupiñan-Rodríguez, Annelié</creatorcontrib><creatorcontrib>Vázquez-Mojena, Yaimeé</creatorcontrib><creatorcontrib>González-Zaldivar, Yanetza</creatorcontrib><creatorcontrib>Laffita Mesa, Jose M.</creatorcontrib><title>Executive deficit in spinocerebellar ataxia type 2 is related to expanded CAG repeats: Evidence from antisaccadic eye movements</title><title>Brain and cognition</title><addtitle>Brain Cogn</addtitle><description>Although antisaccadic task is a sensitive research tool in psychopathology, it has not been systematically studied in patients with spinocerebellar ataxia type 2 (SCA2). 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Prion diseases</subject><subject>Executive dysfunctions</subject><subject>Female</subject><subject>Gene Frequency - genetics</subject><subject>Humans</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Neurology</subject><subject>Organic mental disorders. Neuropsychology</subject><subject>Psychology. Psychoanalysis. Psychiatry</subject><subject>Psychopathology. Psychiatry</subject><subject>Repetitive Sequences, Nucleic Acid</subject><subject>Saccades</subject><subject>Spinocerebellar ataxias</subject><subject>Spinocerebellar Ataxias - genetics</subject><subject>Young Adult</subject><issn>0278-2626</issn><issn>1090-2147</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2014</creationdate><recordtype>article</recordtype><recordid>eNqNkU2LFDEQhoMo7rj6CwTJRfDSbSXp7qQFD8swrsKCFz2HdFKBDNMfJplh5rR_3Ywz6k08JYSnqt7UQ8hrBjUD1r3f1oOZnK05sKYGWQPIJ2TFoIeKs0Y-JSvgUlW8490NeZHSFgD6hvPn5Ia3TPW9UCvyuDmi3edwQOrQBxsyDRNNS5hmixEH3O1MpCabYzA0nxaknIZEI-5MRkfzTPG4lBjlvr67L-8Lmpw-0M0hOJwsUh_nkZoph2SsNS5Yiiek43zAEaecXpJn3uwSvrqet-T7p8239efq4ev9l_XdQ2VL4lzxdvDojR9a2_MODYMG0UsLslFSdKBakC23nYKh64WT3tuGgW1RKemUV-KWvLv0XeL8Y48p6zEke_7dhPM-adaJFhouuPgPlPd9JzhrCyouqI1zShG9XmIYTTxpBvosSW_1L0n6LEmD1EVSqXpzHbAfRnR_an5bKcDbK2CSNTsfzWRD-sv1IFgLULiPFw7L5g4Bo042nLfuQkSbtZvDP4P8BEuRsS0</recordid><startdate>20141101</startdate><enddate>20141101</enddate><creator>Rodríguez-Labrada, Roberto</creator><creator>Velázquez-Pérez, Luis</creator><creator>Aguilera-Rodríguez, Raúl</creator><creator>Seifried-Oberschmidt, Carola</creator><creator>Peña-Acosta, Arnoy</creator><creator>Canales-Ochoa, Nalia</creator><creator>Medrano-Montero, Jacqueline</creator><creator>Estupiñan-Rodríguez, Annelié</creator><creator>Vázquez-Mojena, Yaimeé</creator><creator>González-Zaldivar, Yanetza</creator><creator>Laffita Mesa, Jose M.</creator><general>Elsevier Inc</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>7TK</scope></search><sort><creationdate>20141101</creationdate><title>Executive deficit in spinocerebellar ataxia type 2 is related to expanded CAG repeats: Evidence from antisaccadic eye movements</title><author>Rodríguez-Labrada, Roberto ; Velázquez-Pérez, Luis ; Aguilera-Rodríguez, Raúl ; Seifried-Oberschmidt, Carola ; Peña-Acosta, Arnoy ; Canales-Ochoa, Nalia ; Medrano-Montero, Jacqueline ; Estupiñan-Rodríguez, Annelié ; Vázquez-Mojena, Yaimeé ; González-Zaldivar, Yanetza ; Laffita Mesa, Jose M.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c422t-25bfefafb5c926ea104eef7c07487360850752c680b693d7ffc410c5e887d8f83</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2014</creationdate><topic>Adolescent</topic><topic>Adult</topic><topic>Adult and adolescent clinical studies</topic><topic>Alleles</topic><topic>Antisaccades</topic><topic>Biological and medical sciences</topic><topic>Biomarkers</topic><topic>Biomarkers - analysis</topic><topic>Brain Stem - physiopathology</topic><topic>CAG repeats</topic><topic>Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases</topic><topic>Executive dysfunctions</topic><topic>Female</topic><topic>Gene Frequency - genetics</topic><topic>Humans</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Neurology</topic><topic>Organic mental disorders. Neuropsychology</topic><topic>Psychology. Psychoanalysis. Psychiatry</topic><topic>Psychopathology. Psychiatry</topic><topic>Repetitive Sequences, Nucleic Acid</topic><topic>Saccades</topic><topic>Spinocerebellar ataxias</topic><topic>Spinocerebellar Ataxias - genetics</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Rodríguez-Labrada, Roberto</creatorcontrib><creatorcontrib>Velázquez-Pérez, Luis</creatorcontrib><creatorcontrib>Aguilera-Rodríguez, Raúl</creatorcontrib><creatorcontrib>Seifried-Oberschmidt, Carola</creatorcontrib><creatorcontrib>Peña-Acosta, Arnoy</creatorcontrib><creatorcontrib>Canales-Ochoa, Nalia</creatorcontrib><creatorcontrib>Medrano-Montero, Jacqueline</creatorcontrib><creatorcontrib>Estupiñan-Rodríguez, Annelié</creatorcontrib><creatorcontrib>Vázquez-Mojena, Yaimeé</creatorcontrib><creatorcontrib>González-Zaldivar, Yanetza</creatorcontrib><creatorcontrib>Laffita Mesa, Jose M.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>Neurosciences Abstracts</collection><jtitle>Brain and cognition</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Rodríguez-Labrada, Roberto</au><au>Velázquez-Pérez, Luis</au><au>Aguilera-Rodríguez, Raúl</au><au>Seifried-Oberschmidt, Carola</au><au>Peña-Acosta, Arnoy</au><au>Canales-Ochoa, Nalia</au><au>Medrano-Montero, Jacqueline</au><au>Estupiñan-Rodríguez, Annelié</au><au>Vázquez-Mojena, Yaimeé</au><au>González-Zaldivar, Yanetza</au><au>Laffita Mesa, Jose M.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Executive deficit in spinocerebellar ataxia type 2 is related to expanded CAG repeats: Evidence from antisaccadic eye movements</atitle><jtitle>Brain and cognition</jtitle><addtitle>Brain Cogn</addtitle><date>2014-11-01</date><risdate>2014</risdate><volume>91</volume><spage>28</spage><epage>34</epage><pages>28-34</pages><issn>0278-2626</issn><eissn>1090-2147</eissn><coden>BRCOEI</coden><abstract>Although antisaccadic task is a sensitive research tool in psychopathology, it has not been systematically studied in patients with spinocerebellar ataxia type 2 (SCA2). To identify putative biomarkers of executive dysfunction in SCA2 we assessed the antisaccade performance in 41 SCA2 patients and their sex-and-age matched controls using an electronystagmography device. We studied the relationship between findings in the antisaccade task and CAG repeat length and motor function as assessed using the Scale for the Assessment and Rating of Ataxia (SARA), Nine-Hole Pegboard Test and a validated battery for executive dysfunctions. SCA2 patients showed a significant increase of inhibition and omission antisaccadic error rates, decrease of corrected antisaccadic errors and prolongation of antisaccadic latency and antisaccadic correction latency. Multiple regression predictions identified the expanded CAG repeat as a significant contributing factor on inhibition antisaccadic error rate and percentage of corrected antisaccadic errors. Impaired antisaccadic performance was associated to higher Stroop interference task and verbal fluency test deficits. In conclusion, antisaccadic eye movement abnormalities are a newly recognized association with the genetic abnormality in SCA2 and correlate with executive dysfunction in SCA2. Antisaccade parameters are a promising source of cognitive biomarkers for exploring the disease pathophysiology, and assessing the efficacy of therapeutic options.</abstract><cop>Amsterdam</cop><pub>Elsevier Inc</pub><pmid>25189938</pmid><doi>10.1016/j.bandc.2014.07.007</doi><tpages>7</tpages></addata></record> |
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subjects | Adolescent Adult Adult and adolescent clinical studies Alleles Antisaccades Biological and medical sciences Biomarkers Biomarkers - analysis Brain Stem - physiopathology CAG repeats Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases Executive dysfunctions Female Gene Frequency - genetics Humans Male Medical sciences Middle Aged Neurology Organic mental disorders. Neuropsychology Psychology. Psychoanalysis. Psychiatry Psychopathology. Psychiatry Repetitive Sequences, Nucleic Acid Saccades Spinocerebellar ataxias Spinocerebellar Ataxias - genetics Young Adult |
title | Executive deficit in spinocerebellar ataxia type 2 is related to expanded CAG repeats: Evidence from antisaccadic eye movements |
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