The role of a metabolic intermediate in the biodegradation of inhibitory substrates

Biodegradation of the mixed inhibitory substrates, 2,4-dichlorophenoxyacetic acid (2,4-D) and para-chloro-ortho-cresol (PCOC) was studied in aerobic batch cultures. Each substrate added beyond certain concentrations inhibited the degradation of the other. This mutual inhibition was found to be enhan...

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Bibliographic Details
Published in:Water science and technology 1997, Vol.36 (10), p.27-36
Main Authors: Mungkarndee, P., Rao Bhamidimarri, S.M., Mawson, A.J., Chong, R.
Format: Article
Language:English
Subjects:
2,4-D
2,4-dichiorophenol
2,4-Dichlorophenol
2,4-dichlorophenoxyacetic acid
Biodegradation
Cresols
Degradation
Dichlorophenoxyacetic acid
metabolic intermediate
Metabolism
para-chloro-ortho-cresol
Substrate inhibition
substrate interaction
Substrates
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Summary:Biodegradation of the mixed inhibitory substrates, 2,4-dichlorophenoxyacetic acid (2,4-D) and para-chloro-ortho-cresol (PCOC) was studied in aerobic batch cultures. Each substrate added beyond certain concentrations inhibited the degradation of the other. This mutual inhibition was found to be enhanced by 2,4-dichlorophenol (2,4-DCP) which is an intermediate metabolic product of 2,4-D. When 2,4-DCP accumulated to approximatelY 40 mg/l degradation of all compounds in the mixed 2,4-D and PCOC substrate system was completely inhibited. The degradation of 2,4-D and PCOC individually was also found to be inhibited by elevated concentrations of 2,4-DCP added externally, while PCOC inhibited the utilization of the intermediate.
ISSN:0273-1223
1996-9732
DOI:10.1016/S0273-1223(97)00639-2