A prospective controlled study to assess the use of mitomycin C in improving the results of esophageal dilatation in post corrosive esophageal stricture in children

Abstract Objectives The aim of this study is to investigate the efficacy of topical application of mitomycin C after dilation in pediatric patients having post corrosive esophageal stricture. Methods Thirty patients with post corrosive esophageal strictures were divided into two groups: 12 patients...

Full description

Saved in:
Bibliographic Details
Published in:International journal of pediatric otorhinolaryngology 2015-01, Vol.79 (1), p.23-25
Main Authors: Sweed, Ahmed S, Fawaz, Samya A, Ezzat, Waleed F, Sabri, Sabri M
Format: Article
Language:English
Subjects:
Administration, Topical
Antibiotics, Antineoplastic - therapeutic use
Burns, Chemical - complications
Caustics
Child
Child, Preschool
Corrosive esophagitis
Deglutition Disorders - etiology
Deglutition Disorders - therapy
Dilatation
Dysphagia
Esophageal dilatation
Esophageal Stenosis - etiology
Esophageal Stenosis - therapy
Esophageal stricture
Esophagoscopy
Female
Humans
Male
Mitomycin - therapeutic use
Otolaryngology
Pediatrics
Prospective Studies
Severity of Illness Index
Topical Mitomycin C
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Abstract Objectives The aim of this study is to investigate the efficacy of topical application of mitomycin C after dilation in pediatric patients having post corrosive esophageal stricture. Methods Thirty patients with post corrosive esophageal strictures were divided into two groups: 12 patients had repeated esophageal dilation without mitomycin C application, 18 patients had repeated esophageal dilation and topical application of mitomycin C. Results There was a highly significant difference in the improvement of dysphagia grade at the end of follow up in the mitomycin C group ( p = 0.005). The number of repetition of dilatation ranged from 2 to 6 (median = 3) in the 1st group, and 2 to 4 (median = 2.5) in the mitomycin C group. There were no adverse effects from the topical application of the mitomycin C. Conclusions Topical application of mitomycin C after oesophageal dilation can be beneficial in improving dysphagia in patients with post corrosive oesophageal stricture.
ISSN:0165-5876
1872-8464
DOI:10.1016/j.ijporl.2014.10.024