Clinical significance of microRNA 138 and cyclin D3 in hepatocellular carcinoma

Abstract Background MicroRNA 138 (miR-138) is recently shown to inhibit tumor growth and block cell cycle arrest of hepatocellular carcinoma (HCC) by targeting cyclin D3 (CCND3). The aim of this study was to investigate the clinical significance of miR-138 and CCND3 in human HCC, which remains uncle...

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Bibliographic Details
Published in:The Journal of surgical research 2015-02, Vol.193 (2), p.718-723
Main Authors: Huang, Bo, MD, Li, Huiwen, MD, Huang, Liyu, MD, Luo, Chaoyuan, MD, Zhang, Ying, MD
Format: Article
Language:English
Subjects:
Carcinoma, Hepatocellular - metabolism
Carcinoma, Hepatocellular - mortality
Carcinoma, Hepatocellular - pathology
China - epidemiology
Cyclin D3
Cyclin D3 - metabolism
Expression
Female
Gene Expression Regulation, Neoplastic
Hepatocellular carcinoma
Humans
Liver - pathology
Liver Neoplasms - metabolism
Liver Neoplasms - mortality
Liver Neoplasms - pathology
Male
MicroRNA-138
MicroRNAs - metabolism
Middle Aged
Prognosis
Surgery
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Summary:Abstract Background MicroRNA 138 (miR-138) is recently shown to inhibit tumor growth and block cell cycle arrest of hepatocellular carcinoma (HCC) by targeting cyclin D3 (CCND3). The aim of this study was to investigate the clinical significance of miR-138 and CCND3 in human HCC, which remains unclear. Methods Quantitative real-time polymerase chain reaction analysis was performed to detect the expression levels of miR-138 and CCND3 messenger RNA (mRNA) in 180 self-pairs of HCC and noncancerous liver tissues. Results Compared with noncancerous liver tissues, the expression levels of miR-138 in HCC tissues were significantly downregulated ( P  
ISSN:0022-4804
1095-8673
DOI:10.1016/j.jss.2014.03.076