HLA-DR4 SUBTYPE AND -B ALLELES IN DQB10302-POSITIVE HAPLOTYPES ASSOCIATED WITH IDDM

We determined the distribution of DR4 subtypes in 309 DQB1*0302‐positive haplotypes found in insulin‐dependent diabetes mellitus (IDDM) patients and 70 control haplotypes present only in healthy family members. An increased frequency of DRB1*0401 allele (74.4% vs. 55.7%, P = 0.003) and a decrease of...

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Published in:European journal of immunogenetics 1997-10, Vol.24 (5), p.357-363
Main Authors: REIJONEN, H., NEJENTSEV, S., TUOKKO, J., KOSKINEN, S., TUOMILEHTO-WOLF, E., ÅKERBLOM, H. K., ILONEN, J., GROUP, THE CHILDHOOD DIABETES IN FINLAND STUDY
Format: Article
Language:English
Subjects:
Biological and medical sciences
Diabetes. Impaired glucose tolerance
Endocrine pancreas. Apud cells (diseases)
Endocrinopathies
Etiopathogenesis. Screening. Investigations. Target tissue resistance
Medical sciences
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Summary:We determined the distribution of DR4 subtypes in 309 DQB1*0302‐positive haplotypes found in insulin‐dependent diabetes mellitus (IDDM) patients and 70 control haplotypes present only in healthy family members. An increased frequency of DRB1*0401 allele (74.4% vs. 55.7%, P = 0.003) and a decrease of DRB1*0404 allele (23.6% vs. 40.0%, P = 0.0064) was revealed. A further analysis of extended haplotypes demonstrated strong linkages between various B alleles and DRB1*04 subtypes. HLA‐B39 was more frequent in DRB1*0404–DQB1*0302‐positive IDDM haplotypes compared with control ones (37.0% vs. 14.3%, P = 0.049), suggesting an involvement of the region telomeric to HLA‐DRB1 in the susceptibility to IDDM.
ISSN:0960-7420
1365-2370
DOI:10.1046/j.1365-2370.1997.d01-108.x