Characterization of hollow fiber hemodialysis membranes : pore size distribution and performance

The effect of two commonly used sterilization methods for artificial kidneys on the morphology and performance of hollow fiber Hemophan hemodialysis membranes was studied. A relatively new membrane characterization method, thermoporometry, was used to determine the pore size distributions and porosi...

Full description

Saved in:
Bibliographic Details
Published in:Journal of membrane science 1992-10, Vol.73 (2-3), p.143-152
Main Authors: BROEK, A. P, TEUNIS, H. A, BARGEMAN, D, SPRENGERS, E. D, SMOLDERS, C. A
Format: Article
Language:English
Subjects:
Artificial membranes and reconstituted systems
Biological and medical sciences
Fundamental and applied biological sciences. Psychology
Membrane physicochemistry
Molecular biophysics
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:The effect of two commonly used sterilization methods for artificial kidneys on the morphology and performance of hollow fiber Hemophan hemodialysis membranes was studied. A relatively new membrane characterization method, thermoporometry, was used to determine the pore size distributions and porosities of the differently treated membrane samples. The samples used for this study were not treated with a concentrated glycerol solution before sterilization. Hemophan was found to have a pore size distribution with pore radii between 1.5 and 12 nm, the volume porosity was 20%. The sample sterilized with ethylene oxide (EtO) had a volume porosity of 18% which was due to decrease of the pore volume of the smallest pores. The applied dry steam sterilization treatment resulted in a drastic collapse of the large pores while smaller pores were formed. The calculated porosity was only 10%. The 'tortuous capillary pore model' was used to predict the performance of the artificial kidneys from the pore size distribution in the membrane material. In vitro dialysis experiments with creatinine and vitamin B12 were carried out to compare the calculated and measured clearance rates. Also the ultrafiltration capacity of the devices was determined. It was found that a reasonable estimation of the ultrafiltration capacity could be made. The calculated clearance rates were systematically underestimated, although the relative dependence of the clearance rates on the applied sterilization methods was approximated reasonably.
ISSN:0376-7388
1873-3123
DOI:10.1016/0376-7388(92)80124-3