The Oxeatamides: Nitrogenous Spongian Diterpenes from the New Zealand Marine Sponge Darwinella oxeata

As part of our ongoing search for novel and bioactive compounds from New Zealand marine organisms, we investigated the extracts of the sponge Darwinella oxeata. NMR-guided fractionation led to the isolation of nine new nitrogenous spongian diterpenes, oxeatamide A (1), iso-oxeatamide A (2), oxeatami...

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Bibliographic Details
Published in:Journal of natural products (Washington, D.C.) D.C.), 2014-10, Vol.77 (10), p.2288-2295
Main Authors: Wojnar, Joanna M, Dowle, Katie O, Northcote, Peter T
Format: Article
Language:English
Subjects:
Animals
Darwinella
Diterpenes - chemistry
Diterpenes - isolation & purification
Marine
Marine Biology
Molecular Structure
New Zealand
Nuclear Magnetic Resonance, Biomolecular
Porifera - chemistry
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Summary:As part of our ongoing search for novel and bioactive compounds from New Zealand marine organisms, we investigated the extracts of the sponge Darwinella oxeata. NMR-guided fractionation led to the isolation of nine new nitrogenous spongian diterpenes, oxeatamide A (1), iso-oxeatamide A (2), oxeatamides B–G (3–8), and oxeatamide A 23-methyl ester (9), as well as two known compounds, membranolides C and D (10, 11).
ISSN:0163-3864
1520-6025
DOI:10.1021/np500549g