Hindbrain medulla catecholamine cell group involvement in lactate-sensitive hypoglycemia-associated patterns of hypothalamic norepinephrine and epinephrine activity

Highlights • Insulin-induced hypoglycemia (IIH) is exacerbated by hindbrain lactate repletion. • IIH augments pAMPKα1/2 protein expression in A1, C1, and A2, but not C2 cells. • Ventricular l -lactate infusion normalizes pAMPKα1/2 level content in A2 and C1 but not A1 cells. • Lactate also regulariz...

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Bibliographic Details
Published in:Neuroscience 2014-10, Vol.278, p.20-30
Main Authors: Shrestha, P.K, Tamrakar, P, Ibrahim, B.A, Briski, K.P
Format: Article
Language:English
Subjects:
A2 noradrenergic neurons
Adrenergic Neurons - drug effects
Adrenergic Neurons - metabolism
AMP-Activated Protein Kinases - metabolism
Animals
Blood Glucose
C1 adrenergic neurons
Corticosterone - blood
Epinephrine - analysis
Epinephrine - metabolism
Hypoglycemia - chemically induced
Hypoglycemia - metabolism
Hypothalamus - metabolism
Insulin - pharmacology
insulin-induced hypoglycemia
Lactates - metabolism
Lactates - pharmacology
laser-catapult microdissection
Male
Medulla Oblongata - drug effects
Medulla Oblongata - metabolism
Neurology
Norepinephrine - analysis
Norepinephrine - metabolism
pAMPK
Phosphorylation
Rats
Rats, Sprague-Dawley
Western blotting
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Summary:Highlights • Insulin-induced hypoglycemia (IIH) is exacerbated by hindbrain lactate repletion. • IIH augments pAMPKα1/2 protein expression in A1, C1, and A2, but not C2 cells. • Ventricular l -lactate infusion normalizes pAMPKα1/2 level content in A2 and C1 but not A1 cells. • Lactate also regularizes hypothalamic norepinephrine and epinephrine content in a site-specific manner. • IIH-associated lactoprivation is selectively signaled to the hypothalamus by A2 and C1 cells.
ISSN:0306-4522
1873-7544
DOI:10.1016/j.neuroscience.2014.07.033