Default mode network subsystem alterations in obsessive–compulsive disorder

Although neurobiological models of obsessive-compulsive disorder (OCD) traditionally emphasise the central role of corticostriatal brain regions, studies of default mode network integrity have garnered increasing interest, but have produced conflicting results. To resolve these discrepant findings b...

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Bibliographic Details
Published in:British journal of psychiatry 2014-11, Vol.205 (5), p.376-382
Main Authors: Beucke, Jan C., Sepulcre, Jorge, Eldaief, Mark C., Sebold, Miriam, Kathmann, Norbert, Kaufmann, Christian
Format: Article
Language:English
Subjects:
Adult
Adult and adolescent clinical studies
Anxiety disorders. Neuroses
Biological and medical sciences
Brain - physiopathology
Brain Mapping
Female
Humans
Image Processing, Computer-Assisted
Magnetic Resonance Imaging
Male
Medical sciences
Nerve Net - physiopathology
Obsessive-Compulsive Disorder - diagnosis
Obsessive-Compulsive Disorder - physiopathology
Obsessive-compulsive disorders
Psychology. Psychoanalysis. Psychiatry
Psychopathology. Psychiatry
Severity of Illness Index
Young Adult
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Summary:Although neurobiological models of obsessive-compulsive disorder (OCD) traditionally emphasise the central role of corticostriatal brain regions, studies of default mode network integrity have garnered increasing interest, but have produced conflicting results. To resolve these discrepant findings by examining the integrity of default mode network subsystems in OCD. Comparison of seed-based resting-state functional connectivity of 11 default mode network components between 46 patients with OCD and 46 controls using functional magnetic resonance imaging. Significantly reduced connectivity within the dorsal medial prefrontal cortex self subsystem was identified in the OCD group, and remained significant after controlling for medication status and life-time history of affective disorders. Further, greater connectivity between the self subsystem and salience and attention networks was observed. Results indicate that people with OCD show abnormalities in a neural system previously associated with self-referential processing in healthy individuals, and suggest the need for examination of dynamic interactions between this default mode network subsystem and other large-scale networks in this disorder.
ISSN:0007-1250
1472-1465
DOI:10.1192/bjp.bp.113.137380