Stress-Sensitive Organs and Blood Corticosterone after Immobilization of Active and Passive Rats Immunized with Glutamate–Bovine Serum Albumin Conjugate

We studied stress-induced organ and hormonal responses in behaviorally active and passive rats against the background of immunization with glutamate–BSA conjugate. The relative weight of the adrenal glands after immobilization was lower in rats immunized with the conjugate in comparison with non-imm...

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Bibliographic Details
Published in:Bulletin of experimental biology and medicine 2014-12, Vol.158 (2), p.177-180
Main Authors: Umryukhin, A. E., Sotnikov, S. V., Chekmareva, N. Yu, Vetrile, L. A., Zakharova, I. A.
Format: Article
Language:English
Subjects:
Adrenal Glands - physiology
Albumin
Analysis of Variance
Animals
Biomedical and Life Sciences
Biomedicine
Cattle
Cell Biology
Corticosterone
Corticosterone - blood
Glutamate
Glutamic Acid - administration & dosage
Glutamic Acid - pharmacology
Hypothalamo-Hypophyseal System - drug effects
Hypothalamo-Hypophyseal System - physiology
Immobilization
Immunization
Internal Medicine
Laboratory Medicine
Male
Organ Size - physiology
Pathology
Physiology
Pituitary-Adrenal System - drug effects
Pituitary-Adrenal System - physiology
Rats
Rats, Wistar
Serum Albumin, Bovine - administration & dosage
Serum Albumin, Bovine - pharmacology
Steroids
Stress (Psychology)
Stress, Physiological - physiology
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Summary:We studied stress-induced organ and hormonal responses in behaviorally active and passive rats against the background of immunization with glutamate–BSA conjugate. The relative weight of the adrenal glands after immobilization was lower in rats immunized with the conjugate in comparison with non-immunized animals. The weight of the adrenal glands in behaviorally active rats decreased in parallel with the decrease in blood corticosterone. In behaviorally active and passive rats immunized with the conjugate, ulcer formation in the stomach was slightly intensified after immobilization. It was hypothesized that immunization with glutamate–BSA conjugate suppresses activity of the hypothalamic–pituitary–adrenal feedback mechanism underlying the production of glucocorticoid hormones, which is manifested in slightly increased ulceration due to attenuation of the gastroprotective action of corticosterone under stress.
ISSN:0007-4888
1573-8221
DOI:10.1007/s10517-014-2716-5