The effect of resveratrol on intimal hyperplasia and endothelial proliferation of rabbit carotid artery anastomosis

• Published in: Interactive cardiovascular and thoracic surgery 2015-01, Vol.20 (1), p.15-20
• Main Authors: Karaarslan, Kemal, Abud, Burcin, Albayrak, Gökhan, Aykut, Koray, Ergür, Bekir Ugur, Silistreli, Erdem
• Format: Article
• Language: English
• Subjects: Anastomosis, Surgical; Animals; Carotid Arteries - drug effects; Carotid Arteries - pathology; Carotid Arteries - surgery; Carotid Intima-Media Thickness; Cell Proliferation - drug effects; Endothelial Cells - drug effects; Endothelial Cells - pathology; Hyperplasia; Male; Models, Animal; Muscle, Smooth, Vascular - drug effects; Muscle, Smooth, Vascular - pathology; Muscle, Smooth, Vascular - surgery; Myocytes, Smooth Muscle - drug effects; Myocytes, Smooth Muscle - pathology; Neointima; Rabbits; Stilbenes - pharmacology; Time Factors
• ISSN: 1569-9293; 1569-9285
• DOI: 10.1093/icvts/ivu316

We assessed the effect of resveratrol on intimal hyperplasia and endothelial proliferation after its use for carotid artery anastomosis in rabbits. Fourteen New Zealand-type male rabbits, weighing a mean of 2-3 kg were selected randomly. Their right carotid arteries were transected and anastomosed side by side using 8/0 polypropylene. The rabbits were divided into two groups with seven in each group. While the rabbits in the first group were accepted as the Control group, the rabbits in the second group were given resveratrol (1 mg/kg/day) for 14 days intravenously. At the end of the 28th day, all the carotid artery segments that were transected and anastomosed and the left carotid arteries that did not undergo surgery were removed and evaluated histologically. The results of histological evaluation were as follows: lumen diameter (P