The effect of resveratrol on intimal hyperplasia and endothelial proliferation of rabbit carotid artery anastomosis

We assessed the effect of resveratrol on intimal hyperplasia and endothelial proliferation after its use for carotid artery anastomosis in rabbits. Fourteen New Zealand-type male rabbits, weighing a mean of 2-3 kg were selected randomly. Their right carotid arteries were transected and anastomosed s...

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Published in:Interactive cardiovascular and thoracic surgery 2015-01, Vol.20 (1), p.15-20
Main Authors: Karaarslan, Kemal, Abud, Burcin, Albayrak, Gökhan, Aykut, Koray, Ergür, Bekir Ugur, Silistreli, Erdem
Format: Article
Language:English
Subjects:
Anastomosis, Surgical
Animals
Carotid Arteries - drug effects
Carotid Arteries - pathology
Carotid Arteries - surgery
Carotid Intima-Media Thickness
Cell Proliferation - drug effects
Endothelial Cells - drug effects
Endothelial Cells - pathology
Hyperplasia
Male
Models, Animal
Muscle, Smooth, Vascular - drug effects
Muscle, Smooth, Vascular - pathology
Muscle, Smooth, Vascular - surgery
Myocytes, Smooth Muscle - drug effects
Myocytes, Smooth Muscle - pathology
Neointima
Rabbits
Stilbenes - pharmacology
Time Factors
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cited_by cdi_FETCH-LOGICAL-c291t-d4934c70bbf33c3566037c206cff0f2d8c3f472640655d6632e87a9d99d1ce753
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creator Karaarslan, Kemal
Abud, Burcin
Albayrak, Gökhan
Aykut, Koray
Ergür, Bekir Ugur
Silistreli, Erdem
description We assessed the effect of resveratrol on intimal hyperplasia and endothelial proliferation after its use for carotid artery anastomosis in rabbits. Fourteen New Zealand-type male rabbits, weighing a mean of 2-3 kg were selected randomly. Their right carotid arteries were transected and anastomosed side by side using 8/0 polypropylene. The rabbits were divided into two groups with seven in each group. While the rabbits in the first group were accepted as the Control group, the rabbits in the second group were given resveratrol (1 mg/kg/day) for 14 days intravenously. At the end of the 28th day, all the carotid artery segments that were transected and anastomosed and the left carotid arteries that did not undergo surgery were removed and evaluated histologically. The results of histological evaluation were as follows: lumen diameter (P
doi_str_mv 10.1093/icvts/ivu316
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Fourteen New Zealand-type male rabbits, weighing a mean of 2-3 kg were selected randomly. Their right carotid arteries were transected and anastomosed side by side using 8/0 polypropylene. The rabbits were divided into two groups with seven in each group. While the rabbits in the first group were accepted as the Control group, the rabbits in the second group were given resveratrol (1 mg/kg/day) for 14 days intravenously. At the end of the 28th day, all the carotid artery segments that were transected and anastomosed and the left carotid arteries that did not undergo surgery were removed and evaluated histologically. The results of histological evaluation were as follows: lumen diameter (P &lt;0.001) and lumen area (P &lt;0.05) of the Resveratrol group were larger than those of the Control group, intimal thickness (P &lt;0.05) and media thickness of the Resveratrol group (P = 0.04) were thinner than those of the Control group, and intima/media ratio of the Control group was found to be greater than that of the Resveratrol group (P = 0.002). Resveratrol can prevent intimal hyperplasia and endothelial proliferation following surgical anastomosis.</description><identifier>ISSN: 1569-9293</identifier><identifier>EISSN: 1569-9285</identifier><identifier>DOI: 10.1093/icvts/ivu316</identifier><identifier>PMID: 25269652</identifier><language>eng</language><publisher>England</publisher><subject>Anastomosis, Surgical ; Animals ; Carotid Arteries - drug effects ; Carotid Arteries - pathology ; Carotid Arteries - surgery ; Carotid Intima-Media Thickness ; Cell Proliferation - drug effects ; Endothelial Cells - drug effects ; Endothelial Cells - pathology ; Hyperplasia ; Male ; Models, Animal ; Muscle, Smooth, Vascular - drug effects ; Muscle, Smooth, Vascular - pathology ; Muscle, Smooth, Vascular - surgery ; Myocytes, Smooth Muscle - drug effects ; Myocytes, Smooth Muscle - pathology ; Neointima ; Rabbits ; Stilbenes - pharmacology ; Time Factors</subject><ispartof>Interactive cardiovascular and thoracic surgery, 2015-01, Vol.20 (1), p.15-20</ispartof><rights>The Author 2014. 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The results of histological evaluation were as follows: lumen diameter (P &lt;0.001) and lumen area (P &lt;0.05) of the Resveratrol group were larger than those of the Control group, intimal thickness (P &lt;0.05) and media thickness of the Resveratrol group (P = 0.04) were thinner than those of the Control group, and intima/media ratio of the Control group was found to be greater than that of the Resveratrol group (P = 0.002). Resveratrol can prevent intimal hyperplasia and endothelial proliferation following surgical anastomosis.</abstract><cop>England</cop><pmid>25269652</pmid><doi>10.1093/icvts/ivu316</doi><tpages>6</tpages></addata></record>
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subjects Anastomosis, Surgical
Animals
Carotid Arteries - drug effects
Carotid Arteries - pathology
Carotid Arteries - surgery
Carotid Intima-Media Thickness
Cell Proliferation - drug effects
Endothelial Cells - drug effects
Endothelial Cells - pathology
Hyperplasia
Male
Models, Animal
Muscle, Smooth, Vascular - drug effects
Muscle, Smooth, Vascular - pathology
Muscle, Smooth, Vascular - surgery
Myocytes, Smooth Muscle - drug effects
Myocytes, Smooth Muscle - pathology
Neointima
Rabbits
Stilbenes - pharmacology
Time Factors
title The effect of resveratrol on intimal hyperplasia and endothelial proliferation of rabbit carotid artery anastomosis
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