Is depression associated with increased oxidative stress? A systematic review and meta-analysis

Highlights • A meta-analysis on oxidative stress in depression (uni- and bipolar) was performed. • 10 studies (1308 subjects) on 8-OHdG in depression were included. • 8 studies (2471 subjects) on F2-isoprostanes in depression were included. • Overall oxidative stress was found to be increased in dep...

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Bibliographic Details
Published in:Psychoneuroendocrinology 2015-01, Vol.51, p.164-175
Main Authors: Black, Catherine N, Bot, Mariska, Scheffer, Peter G, Cuijpers, Pim, Penninx, Brenda W.J.H
Format: Article
Language:English
Subjects:
8-Hydroxy-2′-deoxyguanosine (8-OHdG)
Biomarkers - metabolism
Bipolar disorder
Bipolar Disorder - metabolism
Deoxyguanosine - analogs & derivatives
Deoxyguanosine - metabolism
Depression
Depression - metabolism
Depressive Disorder, Major - metabolism
Endocrinology & Metabolism
F2-isoprostanes
F2-Isoprostanes - metabolism
Humans
Major depressive disorder
Oxidative stress
Oxidative Stress - physiology
Psychiatry
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Summary:Highlights • A meta-analysis on oxidative stress in depression (uni- and bipolar) was performed. • 10 studies (1308 subjects) on 8-OHdG in depression were included. • 8 studies (2471 subjects) on F2-isoprostanes in depression were included. • Overall oxidative stress was found to be increased in depression.
ISSN:0306-4530
1873-3360
DOI:10.1016/j.psyneuen.2014.09.025