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Alterations in HPA-axis and autonomic nervous system functioning in childhood anxiety disorders point to a chronic stress hypothesis

Highlights • Children with AD have specific psychophysiological characteristics, which resemble the psychophysiological characteristics of chronic stress. • A high clinical burden is associated with altered ANS and HPA-axis functioning. • Children with specific phobia can be discerned from children...

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Published in:	Psychoneuroendocrinology 2015-01, Vol.51, p.135-150
Main Authors:	Dieleman, Gwendolyn C, Huizink, Anja C, Tulen, Joke H.M, Utens, Elisabeth M.W.J, Creemers, Hanneke E, van der Ende, Jan, Verhulst, Frank C
Format:	Article
Language:	English
Subjects:	Anxiety disorder Anxiety Disorders - diagnosis Anxiety Disorders - physiopathology Autonomic nervous system Autonomic Nervous System - physiopathology Child Circadian Rhythm - physiology Comorbidity, Severity Cortisol Diagnosis, Differential Endocrinology & Metabolism Female HPA-axis Humans Hydrocortisone - analysis Hypothalamo-Hypophyseal System - physiopathology Male Pituitary-Adrenal System - physiopathology Psychiatry Psychophysiology Saliva - chemistry Stress, Perceived arousal Stress, Psychological - physiopathology Surveys and Questionnaires
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description	Highlights • Children with AD have specific psychophysiological characteristics, which resemble the psychophysiological characteristics of chronic stress. • A high clinical burden is associated with altered ANS and HPA-axis functioning. • Children with specific phobia can be discerned from children with social phobia and separation anxiety disorder on higher skin conductance level.
doi_str_mv	10.1016/j.psyneuen.2014.09.002
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subjects	Anxiety disorder Anxiety Disorders - diagnosis Anxiety Disorders - physiopathology Autonomic nervous system Autonomic Nervous System - physiopathology Child Circadian Rhythm - physiology Comorbidity, Severity Cortisol Diagnosis, Differential Endocrinology & Metabolism Female HPA-axis Humans Hydrocortisone - analysis Hypothalamo-Hypophyseal System - physiopathology Male Pituitary-Adrenal System - physiopathology Psychiatry Psychophysiology Saliva - chemistry Stress, Perceived arousal Stress, Psychological - physiopathology Surveys and Questionnaires
title	Alterations in HPA-axis and autonomic nervous system functioning in childhood anxiety disorders point to a chronic stress hypothesis
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