Gene mutations in small-cell lung cancer (SCLC): Results of a panel of 6 genes in a cohort of Italian patients

Highlights • We investigated the presence of mutations in a panel of 6 genes in 113 SCLCs. • We could identify only 7 mutations, 2 in EGFR and 5 in c-MET gene. • EGFR mutations seem to be related to female gender and low tobacco exposure. • c-MET mutations do not show any correlation with specific f...

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Bibliographic Details
Published in:Lung cancer (Amsterdam, Netherlands) Netherlands), 2014-12, Vol.86 (3), p.324-328
Main Authors: Bordi, Paola, Tiseo, Marcello, Barbieri, Fausto, Bavieri, Mario, Sartori, Giuliana, Marchetti, Antonio, Buttitta, Fiamma, Bortesi, Beatrice, Ambrosini-Spaltro, Andrea, Gnetti, Letizia, Silini, Enrico Maria, Ardizzoni, Andrea, Rossi, Giulio
Format: Article
Language:English
Subjects:
Adult
Aged
Aged, 80 and over
Biological and medical sciences
BRAF
c-KIT
c-MET
Disease-Free Survival
EGFR
Female
Gene Expression Regulation, Neoplastic
Gene mutations
Hematology, Oncology and Palliative Medicine
Humans
KRAS
Male
Medical sciences
Middle Aged
Molecular Targeted Therapy
Multiple tumors. Solid tumors. Tumors in childhood (general aspects)
Mutation
PDGFRa
Pneumology
Proto-Oncogene Proteins - biosynthesis
Proto-Oncogene Proteins - genetics
Proto-Oncogene Proteins B-raf - biosynthesis
Proto-Oncogene Proteins B-raf - genetics
Proto-Oncogene Proteins c-kit - biosynthesis
Proto-Oncogene Proteins c-kit - genetics
Proto-Oncogene Proteins c-met - biosynthesis
Proto-Oncogene Proteins c-met - genetics
Proto-Oncogene Proteins p21(ras)
Pulmonary/Respiratory
ras Proteins - biosynthesis
ras Proteins - genetics
Receptor, Epidermal Growth Factor - biosynthesis
Receptor, Epidermal Growth Factor - genetics
Receptor, Platelet-Derived Growth Factor beta - biosynthesis
Receptor, Platelet-Derived Growth Factor beta - genetics
SCLC
Small Cell Lung Carcinoma - drug therapy
Small Cell Lung Carcinoma - genetics
Small Cell Lung Carcinoma - pathology
Tumors
Tumors of the respiratory system and mediastinum
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Summary:Highlights • We investigated the presence of mutations in a panel of 6 genes in 113 SCLCs. • We could identify only 7 mutations, 2 in EGFR and 5 in c-MET gene. • EGFR mutations seem to be related to female gender and low tobacco exposure. • c-MET mutations do not show any correlation with specific features. • Studies with c-MET and EGFR-directed therapies are warranted also in SCLC.
ISSN:0169-5002
1872-8332
DOI:10.1016/j.lungcan.2014.10.002