Isolation of (–)–Avenaciolide as the Antifungal and Antimycobacterial Constituent of a Seimatosporium sp. Endophyte from the Medicinal Plant Hypericum perforatum

An extract of Seimatosporium sp., an endophyte from the Canadian medicinal plant Hypericum perforatum, exhibited significant antifungal and antimycobacterial activity against Candida albicans and Mycobacterium tuberculosis H37Ra. Bioassay guided fractionation led to the isolation of (-)–avenaciolide...

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Bibliographic Details
Published in:Natural product communications 2014-10, Vol.9 (10), p.1495-1496
Main Authors: Clark, Trevor N., Bishop, Amanda I., McLaughlin, Mark, Calhoun, Larry A., Johnson, John A., Gray, Christopher A.
Format: Article
Language:English
Subjects:
Anti-Bacterial Agents - chemistry
Anti-Bacterial Agents - pharmacology
Antifungal Agents - chemistry
Antifungal Agents - pharmacology
Candida albicans - drug effects
Hypericum - chemistry
Lactones - chemistry
Lactones - pharmacology
Microbial Sensitivity Tests
Mycobacterium tuberculosis - drug effects
Plants, Medicinal - chemistry
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Summary:An extract of Seimatosporium sp., an endophyte from the Canadian medicinal plant Hypericum perforatum, exhibited significant antifungal and antimycobacterial activity against Candida albicans and Mycobacterium tuberculosis H37Ra. Bioassay guided fractionation led to the isolation of (-)–avenaciolide as the only bioactive constituent of the extract. This is the first report of both the antimycobacterial activity of avenaciolide and its isolation from a Seimatosporium sp. fungus.
ISSN:1934-578X
1555-9475
DOI:10.1177/1934578X1400901022