Effects of Cadmium On Liver Function in Diabetic Rats

Hepato-toxicity of cadmium in alloxan induced diabetic rats has been studied by estimating a few enzymes viz serum glutamic oxalacetic transaminase, glutamic pyruvic transaminase, alkaline phosphatase and γ-glutamyltranspeptidase. Present results suggest that cadmium manifests difterent effects in n...

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Bibliographic Details
Published in:Toxicology and industrial health 1998-05, Vol.14 (3), p.473-477
Main Authors: Rana, Suresh V.S., Rastogi, Nidhi
Format: Article
Language:English
Subjects:
Alanine Transaminase - metabolism
Alkaline Phosphatase - metabolism
Animals
Aspartate Aminotransferases - metabolism
Cadmium - toxicity
Diabetes Mellitus, Experimental - etiology
Diet
gamma-Glutamyltransferase - metabolism
Liver - drug effects
Male
Rats
Rats, Inbred Strains
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Summary:Hepato-toxicity of cadmium in alloxan induced diabetic rats has been studied by estimating a few enzymes viz serum glutamic oxalacetic transaminase, glutamic pyruvic transaminase, alkaline phosphatase and γ-glutamyltranspeptidase. Present results suggest that cadmium manifests difterent effects in normal and diabetic rats. Insulin therapy helps in restoring the liver function. It is suggested that an isozyme of cytochrome P450 that appears in diabetic rats might be responsible for altered toxicity of cadmium.
ISSN:0748-2337
1477-0393
DOI:10.1177/074823379801400306