Formation and secretion of a new brown benzoquinone by hairy root cultures of Lithospermum erythrorhizon

A new brown quinone, named hydroxyechinofuran B, was produced and secreted by hairy roots of Lithospermum erythrorhizon cultured in Murashige-Skoog liquid medium that is not appropriate for shikonin production. Hairy roots of Lithospermum erythrorhizon in Murashige-Skoog medium produce a new brown b...

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Bibliographic Details
Published in:Phytochemistry (Oxford) 1998-03, Vol.47 (6), p.1037-1039
Main Authors: Fukui, Hiroshi, Feroj Hasan, A.F.M., Ueoka, Tomohiro, Kyo, Masaharu
Format: Article
Language:English
Subjects:
benzoquinone
Biological and medical sciences
Biotechnology
Boraginaceae
echinofuran
Fundamental and applied biological sciences. Psychology
Genetic engineering
Genetic technics
hairy root cultures
hydroxyechinofuran B
Lithospermum erythrorhizon
Methods. Procedures. Technologies
secretion
shikonin
Transgenic animals and transgenic plants
Transgenic plants
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Summary:A new brown quinone, named hydroxyechinofuran B, was produced and secreted by hairy roots of Lithospermum erythrorhizon cultured in Murashige-Skoog liquid medium that is not appropriate for shikonin production. Hairy roots of Lithospermum erythrorhizon in Murashige-Skoog medium produce a new brown benzoquinone derivative instead of red naphthoquinone (shikonin) derivatives as the main secondary metabolites. The structure of the new quinone was elucidated to be 2-[4-( E-4-hydroxymethyl-3-pentenyl)-furan-2-yl]-1,4-benzoquinone (called hydroxyechinofuran B) based on spectroscopic data. Its biosynthesis may be via geranylhydroquinone, a key biosynthetic intermediate of shikonin.
ISSN:0031-9422
1873-3700
DOI:10.1016/S0031-9422(98)80067-8