Could physical exercises modulate Nrf2–Keap1 pathway in chronic kidney disease?

Abstract Patients with chronic kidney disease (CKD) have various metabolic disorders caused by a chronic state of oxidative stress and inflammation, and recently, nuclear factor-erythroid 2-related factor 2 (Nrf2) has emerged as a factor that plays a significant role in cellular protection against o...

Full description

Saved in:
Bibliographic Details
Published in:Medical hypotheses 2015-01, Vol.84 (1), p.44-46
Main Authors: Abreu, C.C, Cardozo, L.F.M.F, Mafra, D
Format: Article
Language:English
Subjects:
Exercise - physiology
Humans
Internal Medicine
Intracellular Signaling Peptides and Proteins - metabolism
Kelch-Like ECH-Associated Protein 1
Models, Biological
NF-E2-Related Factor 2 - metabolism
Oxidative Stress - physiology
Renal Insufficiency, Chronic - physiopathology
Signal Transduction - physiology
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Abstract Patients with chronic kidney disease (CKD) have various metabolic disorders caused by a chronic state of oxidative stress and inflammation, and recently, nuclear factor-erythroid 2-related factor 2 (Nrf2) has emerged as a factor that plays a significant role in cellular protection against oxidative stress and inflammation. This transcription factor when activated can regulate antioxidant and anti-inflammatory cellular responses leading to the expression of detoxifying enzymes. Studies have shown that Nrf2 expression can be modulated by several factors, such as bioactive compounds and physical exercise. In fact, exercise in CKD patients can bring many benefits; however, there are no studies correlating physical activity and Nrf2 expression in CKD patients. This review aims to discuss whether there is any evidence to justify a recommendation of physical exercise in CKD patients as a non-pharmacological option to activate the Nrf2 pathway.
ISSN:0306-9877
1532-2777
DOI:10.1016/j.mehy.2014.11.013